Department of Pharmocology

Active

Investigating the Drug-Nutrient Interaction of Bioactive Compounds in Dietary Supplements Mediated by Inhibition and Induction of the Atp-Binding Cassette Transporters Abcb1 and Abcg2

Wu, C.-P. (PI) & Hung, T.-H. (CoPI)

01/08/24 → 31/07/25

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Establishment of Translational Precision Medicine for Early Detection of Advanced Head and Neck Cancer: from Animal Model to Clinic

Lai, K.-C. (PI) & Hsieh, C. H. (CoPI)

01/08/24 → 31/07/25

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Finished

Identification of Inhibitors of Abcb1 Using Molecular Docking-Guided Drug Repositioning Approaches

Wu, C.-P. (PI)

01/08/23 → 31/07/24

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Establishment of Translational Precision Medicine for Early Detection of Advanced Head and Neck Cancer: from Animal Model to Clinic

Lai, K.-C. (PI) & Hsieh, C. H. (CoPI)

01/08/23 → 31/07/24

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Investigation of the Mechanisms of Ifit2 Depletion-Induced Cancer Cachexia in Head and Neck Cancer (Second-Year Extension)

Lai, K.-C. (PI), Hsieh, C. H. (CoPI) & Yang, C. H. (CoPI)

01/08/23 → 31/07/24

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Aptamers as Targeting Ligands in Thromboembolic Theranostics( III )

Ma, Y.-H. (PI), Chen, J.-P. (CoPI), Huang, C. C. (CoPI) & Lin, Y. L. (CoPI)

01/08/22 → 31/07/23

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Investigation of the Mechanisms of Ifit2 Depletion-Induced Cancer Cachexia in Head and Neck Cancer (Second-Year Extension)

Lai, K.-C. (PI), Hsieh, C. H. (CoPI) & Yang, C. H. (CoPI)

01/08/22 → 31/07/23

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Evaluation of Multidrug Resistance-Linked Atp-Binding Cassette Drug Transporter-Mediated Drug-Drug Interactions of Molecularly Targeted Agents in Combination Chemotherapy

Wu, C.-P. (PI)

01/08/22 → 31/07/23

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

A Systematic Approach to Identify Novel Inhibitors of Multidrug-Resistance Associated Proteins from Purified Natural Products: Drug Screening, in Vitro and in Vivo Model Systems

Wu, C.-P. (PI)

01/08/21 → 31/07/22

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Investigation of the Mechanisms of Ifit2 Depletion-Induced Cancer Cachexia in Head and Neck Cancer (Second-Year Extension)

Lai, K.-C. (PI), Hsieh, C. H. (CoPI) & Yang, C. H. (CoPI)

01/08/21 → 31/07/22

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Pathophysiological Role of Mitophagy and Mitochondrial Permeability Transition during Mitochondrial Stress

Jou, M.-J. (PI)

01/08/21 → 31/07/22

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Aptamers as Targeting Ligands in Thromboembolic Theranostics( II )

Ma, Y.-H. (PI), Chen, J.-P. (CoPI), Huang, C. C. (CoPI) & Lin, Y. L. (CoPI)

01/08/21 → 31/07/22

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Mechanisms of Pegylated Nanoparticle-Induced Transient Hypotension and Tachyphylaxis

Ma, Y.-H. (PI)

01/08/20 → 31/07/21

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Investigation of the Mechanisms of Ifit2 Depletion-Induced Cancer Cachexia in Head and Neck Cancer

Lai, K.-C. (PI) & Yang, M.-H. (CoPI)

01/08/20 → 31/07/21

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

A Systematic Approach to Identify Novel Inhibitors of Multidrug-Resistance Associated Proteins from Purified Natural Products: Drug Screening, in Vitro and in Vivo Model Systems

Wu, C.-P. (PI)

01/08/20 → 31/07/21

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Aptamers as Targeting Ligands in Thromboembolic Theranostics( I )

Ma, Y.-H. (PI), Chen, J.-P. (CoPI), Huang, C. C. (CoPI), Lai, W.-F. (CoPI) & Lin, Y. L. (CoPI)

01/08/20 → 31/07/21

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Pegylated Nanoparticle-Induced Hypotensive Effects: Nanotoxicology in Cardiovascular System

Ma, Y.-H. (PI)

01/08/19 → 31/07/20

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Application of Drug Screening and Drug Repositioning Strategy to Overcome Cancer Multidrug Resistance Mediated by Abcb1 or Abcg2

Wu, C.-P. (PI)

01/08/19 → 31/07/20

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

A Systematic Approach to Identify Novel Inhibitors of Multidrug-Resistance Associated Proteins from Purified Natural Products: Drug Screening, in Vitro and in Vivo Model Systems

Wu, C.-P. (PI)

01/08/19 → 31/07/20

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Pathophysiological Roles of Transient Mitochondrial Permeability Transition in Mitochondrial Respiratory Chain Defect-Augmented Mitochondrial Stress

Jou, M.-J. (PI) & Peng, T. I. (CoPI)

01/08/19 → 31/07/20

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Overcoming Cancer Multidrug Resistance Mediated by Abcb1 or Abcg2 by Tyrphostins

Wu, C.-P. (PI)

01/08/18 → 31/07/19

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Micrornas Fine-Tune Respiratory Chain Defect-Augmented Mitochondrial Pathological Outcomes in Mitochondrial Diseases

Jou, M.-J. (PI) & Peng, T. I. (CoPI)

01/08/18 → 31/07/19

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Characterization of Glycoconjugate-Nanoparticle Interfaces on the Cell Surface for Optimized Target Delivery

Ma, Y.-H. (PI)

01/08/18 → 31/07/19

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Antioxidative Magnetic Nanoparticles Based on Natural Antioxidants: Nanoparticle-Cell Interactions

Ma, Y.-H. (PI) & Lee, W. C. (CoPI)

01/01/18 → 31/12/18

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Chemical and Magnetic Interplay on the Endocytosis Receptor-Mediated Nanoparticle Internalization by Tumor Cells

Ma, Y.-H. (PI)

01/08/17 → 31/07/18

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

The Pathophysiological Roles of Mirna in Mitochondrial Diseases

Jou, M.-J. (PI) & Peng, T. I. (CoPI)

01/08/17 → 31/07/18

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Developing Natural Product Modulators to Overcome Multidrug Resistance in Cancer Chemotherapy

Wu, C.-P. (PI)

01/08/17 → 31/07/18

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Antioxidative Magnetic Nanoparticles Based on Natural Antioxidants: Nanoparticle-Cell Interactions

Ma, Y.-H. (PI) & Lee, W. C. (CoPI)

01/01/17 → 31/12/17

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Investigation of Drug-Drug Interactions Mediated by the Atp-Binding Cassette Drug Transporters Abcb1 and Abcg2

Wu, C.-P. (PI)

01/08/16 → 31/07/17

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Study the Role of Ca2+-Mediated Cardiolipin Remodeling and Mitochondrial Dynamics in the Pathological “Threshold Effect” of Mitochondrial Diseases

Jou, M.-J. (PI) & Peng, T. I. (CoPI)

01/08/16 → 31/07/17

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Antioxidative magnetic nanoparticles based on natural antioxidants: Nanoparticle-cell interactions

Ma, Y.-H. (PI) & Lee, W. C. (CoPI)

01/01/16 → 31/12/16

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Role of Ca2+-Mediated Cardiolipin Remodeling in Pathological “Threshold Effect” of Mitochondrial Diseases

Jou, M.-J. (PI) & Peng, T. I. (CoPI)

01/08/15 → 31/07/16

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Discovering Novel Modulators and Effective Drug Combination Therapy against Transporter-Mediated Multidrug Resistant Cancers

Wu, C.-P. (PI)

01/08/15 → 31/07/16

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Fluorescence Detection-Based High-Throughput Functional Screening for the Identification of Inhibitors of Human ABCB1 and ABCG2 Proteins

Wu, C.-P. (PI)

01/08/14 → 31/07/15

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Targeting Endothelial Injury with Annexin V for Antithrombotic Therapy

Ma, Y.-H. (PI)

01/08/14 → 31/07/15

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Mechanistic Visualization of Pathophysiological Regulation of Cardiolipin in Mitochondria

Jou, M.-J. (PI) & Peng, T. I. (CoPI)

01/08/14 → 31/07/15

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Mechanistic visualization of pathophysiological regulation of cardiolipin in mitochondria

Jou, M.-J. (PI) & Peng, T. I. (CoPI)

01/08/13 → 31/07/14

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

A Pharmacological Investigation of the Interaction of Major Drug Resistance-Associated ATP-Binding Cassette Proteins with Vemurafenib and Braf Inhibitors in Wild-Type and BRAF(V600E) Mutant Cancers

Wu, C.-P. (PI)

01/08/13 → 31/07/14

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Charaterization and Mechanisms of Green Tea Catechins in Facilitating Cellular Uptake of Nanoparticles

Ma, Y.-H. (PI) & Wu, C. T. (CoPI)

01/08/12 → 31/07/13

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Mechanistic Visualization of Pathophysiological Regulation of Cardiolipin in Mitochondria

Jou, M.-J. (PI) & Peng, T. I. (CoPI)

01/08/12 → 31/07/13

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Enhanced thrombolytic therapy for stroke: Targeted delivery of urokinase with magnetic nanoparticles

Ma, Y.-H. (PI), Chen, J.-P. (CoPI), Liu, H.-L. (CoPI), Tu, S.-J. (CoPI) & Wu, T. S. (CoPI)

01/01/12 → 31/12/12

Project: National Health Research Institutes › National Health Research Institutes Grants Research

Mechanistic Visualization of Mitochondrial Complex I Defects-Induced Mitochondrial Stresses in Astrocytes

Jou, M.-J. (PI) & Peng, T. I. (CoPI)

01/08/11 → 31/07/12

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Intravascular Application of Magnetic Nanoparticle for Target Thrombolysis

Ma, Y.-H. (PI), Chen, J.-P. (CoPI), Liu, H.-L. (CoPI), Tu, S.-J. (CoPI) & Wu, T. S. (CoPI)

01/08/11 → 31/07/12

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Characterization of a Small Molecule Compound Selectively Kills Drug-Selected P-Glycoprotein (Abcb1)-Overexpressing Mdr Cancer Cells by Preferential Induction of Apoptosis and Autophagy

Wu, C.-P. (PI)

01/08/11 → 31/07/12

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Enhanced thrombolytic therapy for stroke: Targeted delivery of urokinase with magnetic nanoparticles

Ma, Y.-H. (PI), Chen, J.-P. (CoPI), Liu, H.-L. (CoPI), Tu, S.-J. (CoPI) & Wu, T. S. (CoPI)

01/01/11 → 31/12/11

Project: National Health Research Institutes › National Health Research Institutes Grants Research

Intravascular Application of Magnetic Nanoparticle for Target Thrombolysis

Ma, Y.-H. (PI), Chen, J.-P. (CoPI), Liu, H.-L. (CoPI), Tu, S.-J. (CoPI) & Wu, T. S. (CoPI)

01/08/10 → 31/07/11

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Mechanistic Visualization of Mitochondrial Complex I Defects-Induced Mitochondrial Stresses in Astrocytes

Jou, M.-J. (PI) & Peng, T. I. (CoPI)

01/08/10 → 31/07/11

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Enhanced thrombolytic therapy for stroke: Targeted delivery of urokinase with magnetic nanoparticles

Ma, Y.-H. (PI), Chen, J.-P. (CoPI), Liu, H.-L. (CoPI), Tu, S.-J. (CoPI) & Wu, T. S. (CoPI)

01/01/10 → 31/12/10

Project: National Health Research Institutes › National Health Research Institutes Grants Research

Intravascular Application of Magnetic Nanoparticle for Target Thrombolysis (I)

Ma, Y.-H. (PI), Chen, J.-P. (CoPI), Liu, H.-L. (CoPI), Tu, S.-J. (CoPI) & Wu, T. S. (CoPI)

01/08/09 → 31/07/10

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Mechanistic Visualization of Mitochondrial Complex I Defects-Induced Mitochondrial Stresses in Astrocytes

Jou, M.-J. (PI) & Peng, T. I. (CoPI)

01/08/09 → 31/07/10

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Department of Pharmocology

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