Graduate Institute of Biomedical Sciences

2025

A genetic basis of mitochondrial DNAJA3 in nonalcoholic steatohepatitis-related hepatocellular carcinoma

Chang, C. W., Chen, Y. S., Huang, C. H., Lin, C. H., Ng, W. V., Chu, L. J., Trépo, E., Zucman-Rossi, J., Siao, K., Maher, J. J., Chiew, M. Y., Chou, C. H., Huang, H. D., Teo, W. H., Lee, I. S., Lo, J. F. & Wang, X. W., 01 01 2025, In: Hepatology. 81, 1, p. 60-76 17 p.

Research output: Contribution to journal › Journal Article › peer-review

Chemical modulation of Akt signaling enhances spinal cord regeneration in zebrafish

Shen, Y. J., Chen, H. Y., Chang, C. W., Huang, Y. C. & Cheng, Y. C., 01 01 2025, In: Brain Research. 1846, p. 149248 149248.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Empagliflozin Reduces High Glucose-Induced Cardiomyopathy in hiPSC-Derived Cardiomyocytes: Glucose-induced Lipotoxicity in hiPSC-Derived Cardiomyocytes

Tsai, H. H., Hsiao, F. C., Yu, A. L., Juang, J. H., Yu, J. & Chu, P. H., 04 2025, In: Stem Cell Reviews and Reports. 21, 3, p. 849-858 10 p.

Research output: Contribution to journal › Journal Article › peer-review

Extracellular vesicles from fifth-stage larval Angiostrongylus cantonensis upregulate cholesterol biosynthesis and suppress NLRP2-associated inflammatory responses in mouse astrocytes

Cheng, C. J., Wang, L. C., Chu, L. J., Chen, K. Y., Huang, C. Y., Lan, K. L. & Huang, K. Y., 21 01 2025, In: mSystems. 10, 1, p. e0101424

Research output: Contribution to journal › Journal Article › peer-review

Open Access

Immunomodulatory roles of autophagic flux and IFIT in human ectocervical cells upon Trichomonas vaginalis infection

Liu, C. C., Chu, L. J., Yeh, Y. M., Lin, H. C., Chen, L. C., Huang, C. Y., Chiu, S. F., Cheng, F. W., Lin, W. N. & Huang, K. Y., 16 05 2025, In: International Immunopharmacology. 155, 114643.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

Integrated multi-omics analyses of oral squamous cell carcinoma reveal precision patient stratification and personalized treatment strategies

Wu, C. S., Li, H. P., Hsieh, C. H., Lin, Y. T., Yi-Feng Chang, I., Chung, A. K., Huang, Y., Ueng, S. H., Hsiao, Y. C., Chien, K. Y., Luo, J. D., Chen, C. H., Liao, W. C., Hung, J. L., Yuan, S. N., OuYang, C. N., Chiang, W. F., Chien, C. Y., Chuang, H. C. & Chu, L. J. & 10 others, Liu, H., Yang, C. Y., Robles, A. I., Rodriguez, H., Lin, H. H., Yang, H. Y., Hsueh, C., Chang, K. P., Yu, J. S. & Chang, Y. S., 01 04 2025, In: Cancer Letters. 614, p. 217482 217482.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

1 Scopus citations

Pathological Role of High Sugar in Mitochondrial Respiratory Chain Defect-Augmented Mitochondrial Stress

陳亞德, 2025, 135 p.

Research output: Types of Thesis › Doctoral thesis

PROTACs as Therapeutic Modalities for Drug Discovery in Castration-Resistant Prostate Cancer

Wang, L. Y., Hung, C. L., Wang, T. C., Hsu, H. C., Kung, H. J. & Lin, K. H., 23 01 2025, In: Annual review of pharmacology and toxicology. 65, 1, p. 375-396 22 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

ST3GAL1 regulates cancer cell migration through crosstalk between EGFR and neuropilin-1 signaling

Fan, T. C., Yeo, H. L., Hung, T. H., Chang, N. C., Tang, Y. H., Yu, J., Chen, S. H. & Yu, A. L., 04 2025, In: Journal of Biological Chemistry. 301, 4, p. 108368 108368.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

Stimulation of dorsal root ganglion with low-intensity focused ultrasound ameliorates pain responses through the GABA inhibitory pathway

Lin, Y. T., Chen, K. T., Hsu, C. C., Liu, H. L., Jiang, Y. T., Ho, C. W., Chen, J. C., Li, H. Y., Weng, C. C. & Hsu, P. H., 15 01 2025, In: Life Sciences. 361, 123323.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

2024

Advancements in Antioxidant-Based Therapeutics for Spinal Cord Injury: A Critical Review of Strategies and Combination Approaches

Shen, Y. J., Huang, Y. C. & Cheng, Y. C., 26 12 2024, In: Antioxidants. 14, 1, 17.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

A historical perspective of Kupffer cells in the context of infection

Graham, C. T., Gordon, S. & Kubes, P., 11 10 2024, (E-pub ahead of print) In: Cell and Tissue Research.

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Benchmarking 13 tools for mutational signature attribution, including a new and improved algorithm

Jiang, N., Wu, Y. & Rozen, S. G., 22 11 2024, In: Briefings in Bioinformatics. 26, 1, bbaf042.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

Brain region specific effect of alpha-synuclein in Parkinson disease dementia

黃予庭, 2024, 158 p.

Research output: Types of Thesis › Doctoral thesis

Clinical validation of a saliva-based matrix metalloproteinase-1 rapid strip test for detection of oral cavity cancer

Chu, L. J., Chang, Y. T., Chien, C. Y., Chung, H. C., Wu, S. F., Chen, C. J., Liu, Y. C., Liao, W. C., Chen, C. H., Chiang, W. F., Chang, K.-P., Wang, J. S. & Yu, J. S., 02 2024, In: Biomedical Journal. 47, 1, p. 100594 100594.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

5 Scopus citations

Detection of toxigenic M1_UK lineage group A Streptococcus clones in Taiwan

Chiang-Ni, C., Hsu, C. Y., Yeh, Y. H., Chi, C. Y., Wang, S., Tsai, P. J. & Chiu, C. H., 04 2024, In: Journal of Microbiology, Immunology and Infection. 57, 2, p. 269-277 9 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

8 Scopus citations

Development and optimization of a DNA aptamer to delay β-bungarotoxin-induced lethality in a rodent model

Liu, C. C., Hsiao, Y. C., Lai, W. J., Chiou, C. C., Chu, L. J., Lin, Y. T., Liu, J. C. & Yu, J. S., 06 2024, In: International Journal of Biological Macromolecules. 270, Pt 2, p. 132240 132240.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Development of antibody-detection ELISA based on beta-bungarotoxin for evaluation of the neutralization potency of equine plasma against Bungarus multicinctus in Taiwan

Liu, C. C., Lin, C. C., Liou, M. H., Hsiao, Y. C., Chu, L. J., Wang, P. J., Liu, C. H., Wang, C. Y., Chen, C. H. & Yu, J. S., 03 2024, In: International Journal of Biological Macromolecules. 262, Pt 2, p. 130080 130080.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

dMRMb:MRM 實驗參數整合性資料庫

Translated title of the contribution: Multiple Reaction Monitoring Database (dMRMb): Integrative database for MRM methods鄭甯之, 2024, 111 p.

Research output: Types of Thesis › Master's thesis

Dtx2 Deficiency Induces Ependymo-Radial Glial Cell Proliferation and Improves Spinal Cord Motor Function Recovery

Chen, H. Y., Huang, Y. C., Yeh, T. H., Chang, C. W., Shen, Y. J., Chen, Y. C., Sun, M. Q. & Cheng, Y. C., 01 10 2024, In: Stem Cells and Development. 33, 19-20, p. 540-550 11 p.

Research output: Contribution to journal › Journal Article › peer-review

Effective suppression of tumor growth and hepatic metastasis of neuroblastoma by NKT-stimulatory phenyl glycolipid

Wu, T. N., Hung, J. T., Hung, T. H., Wang, Y. H., Wu, J. C. & Yu, A. L., 08 2024, In: Biomedicine and Pharmacotherapy. 177, p. 117040 117040.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

3 Scopus citations

Genetic diversity, biofilm formation, and Vancomycin resistance of clinical Clostridium innocuum isolates

Chiang-Ni, C., Huang, J. Y., Hsu, C. Y., Lo, Y. C., Chen, Y. Y. M., Lai, C. H. & Chiu, C. H., 18 09 2024, In: BMC Microbiology. 24, 1, p. 353 353.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

1 Scopus citations

High expression of embryonic stem cell marker SSEA3 confers poor prognosis and promotes epithelial mesenchymal transition in hepatocellular carcinoma

Hung, T. H., Huang, Y., Yeh, C. T., Yeh, C. N., Yu, J., Lin, C. C., Chiou, S. P., Chiang, P. Y., Hung, J. T. & Yu, A. L., 04 2024, In: Biomedical Journal. 47, 2, p. 100612 100612.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

5 Scopus citations

Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus

Lin, Y.-T., Wu, K. H., Jhang, J. J., Jhang, J. L., Yu, Z., Tsai, S. C., Chen, J. C., Hsu, P. H. & Li, H. Y., 03 2024, In: Clinical Nutrition. 43, 3, p. 603-619 17 p.

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Identification of endothelial cell protein c receptor by urinary proteomics as a novel prognostic marker in non-recovery kidney injury

Yang, C.-W., Yu, J.-S., Chen, Y.-T., Chu, L. J., Chu, P.-H., Chang, C.-H., Chen, H.-W., Chen, Y.-C., Lee, C.-C. & Fan, P.-C., 02 2024, In: International Journal of Molecular Sciences. 25, 5, p. 2783 - 2796

Research output: Contribution to journal › Journal Article › peer-review

Identification of Endothelial Cell Protein C Receptor by Urinary Proteomics as Novel Prognostic Marker in Non-Recovery Kidney Injury

Chang, C. H., Lee, C. C., Chen, Y. C., Fan, P. C., Chu, P. H., Chu, L. J., Yu, J. S., Chen, H. W., Yang, C. W. & Chen, Y. T., 28 02 2024, In: International Journal of Molecular Sciences. 25, 5, 2783.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages

Onyishi, C. U., Jeon, Y., Fejer, G., Mukhopadhyay, S., Gordon, S. & May, R. C., 06 2024, In: European Journal of Immunology. 54, 6, p. e2350771 2350771.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

3 Scopus citations

LRP10基因突變在帕金森氏症發展中的角色

Translated title of the contribution: The Role of LRP10 mutations in the Development of Parkinson’s disease陳翊捷, 2024, 48 p.

Research output: Types of Thesis › Master's thesis

Molecular profiling reveals novel therapeutic targets and clonal evolution in ovarian clear cell carcinoma

Chao, A., Huang, C. Y., Yu, W., Lin, C. Y., Lin, H., Chao, A. S., Lin, C. T., Chou, H. H., Huang, K. G., Huang, H. J., Chang, T. C., Rozen, S. G., Wu, R. C. & Lai, C. H., 14 11 2024, In: BMC Cancer. 24, 1, p. 1403 1403.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

1 Scopus citations

Mononuclear Phagocytes, Cellular Immunity, and Nobel Prizes: A Historic Perspective

Gordon, S., Roberti, A. & Kaufmann, S. H. E., 19 08 2024, In: Cells. 13, 16, 1378.

Research output: Contribution to journal › Review article › peer-review

Open Access

Novel Anti-Viral Properties of the Herbal Extract of Davallia mariesii against Influenza A Virus

Chen, Y.-L., Chao, P.-Y., Hsieh, C.-F., Hsieh, P.-W. & Horng, J.-T., 28 03 2024, In: Viruses. 16, 4, 523.

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions

Pan, Y. R., Lai, J. C. Y., Huang, W. K., Peng, P. H., Jung, S. M., Lin, S. H., Chen, C. P., Wu, C. E., Hung, T. H., Yu, A. L., Wu, K. J. & Yeh, C. N., 02 2024, In: Cancer Gene Therapy. 31, 2, p. 322-333 12 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

4 Scopus citations

Selective p300 degradation via peptide PROTAC: a new therapeutic strategy for advanced prostate cancers

Wang, L. Y., 08 2024, In: EBioMedicine. 106, p. 105245 105245.

Research output: Contribution to journal › Comment/debate

Open Access

Suppression of presynaptic corticostriatal glutamate activity attenuates L-dopa-induced dyskinesia in 6-OHDA-lesioned Parkinson's disease mice

Huang, Y. T., Chen, Y. W., Lin, T. Y. & Chen, J. C., 04 2024, In: Neurobiology of Disease. 193, p. 106452 106452.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

3 Scopus citations

Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions

Hu, H.-C., Yu, S.-Y., Tsai, Y.-H., Hsieh, P.-W., Wang, H.-C., Chen, Y.-N., Chuang, Y.-T., Lee, M.-Y., Chang, H.-W., Hu, H.-C., Wu, Y.-C., Chang, F.-R., Szatmári, I. & Fülöp, F., 27 03 2024, In: Organic and Biomolecular Chemistry. 22, 13, p. 2620-2629 10 p.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Systematic Evaluation of Chromatographic Peak Quality for Targeted Mass Spectrometry via Variational Autoencoder

Yang, C., Hsiao, Y. C., Lee, C. C. & Yu, J. S., 02 2024, In: Analytical Chemistry. 96, 7, p. 2849 - 2856 8 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

Temporal and Spatial Variations in Zebrafish Hairy/E(spl) Gene Expression in Response to Mib1-Mediated Notch Signaling During Neurodevelopment

Chen, Y. C., Hsieh, F. Y., Chang, C. W., Sun, M. Q. & Cheng, Y. C., 23 08 2024, In: International Journal of Molecular Sciences. 25, 17, 9174.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

The novel role of LOC344887 in the enhancement of hepatocellular carcinoma progression via modulation of SHP1-regulated STAT3/HMGA2 signaling axis

Lin, Y. H., Chi, H.-C., Wu, M. H., Liao, C. J., Chen, C. Y., Huang, P. S., Huang, W. C., Wang, Y. W., Lin, T. K., Lai, M. W., Yeh, C. T. & Lin, K. H., 2024, In: International Journal of Biological Sciences. 20, 15, p. 6281-6296 16 p.

Research output: Contribution to journal › Journal Article › peer-review

Unifying considerations and evidence of macrophage activation mosaicism through human CSF1R and M1/M2 genes

Orsenigo, F., Stewart, A., Hammer, C. P., Clarke, E., Simpkin, D., Attia, H., Rockall, T., Gordon, S. & Martinez, F. O., 25 06 2024, In: Cell Reports. 43, 6, p. 114352 114352.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

2 Scopus citations

探討EGR3在調節神經膠質母細胞瘤生長中的角色及其潛在機制

Translated title of the contribution: Investigating the Role of EGR3 and Its Underlying Mechanisms in Regulating Glioblastoma Growth周湙瑾, 2024, 57 p.

Research output: Types of Thesis › Master's thesis

開發液相層析-多重反應監測的自動化胜肽參數調校的工作流程

Translated title of the contribution: Development of Automatic workflow for Peptide Parameter Tuning in LC-Based Multiple Reaction Monitoring陳憶涵, 2024, 69 p.

Research output: Types of Thesis › Master's thesis

2023

Anti-GD2合併anti-PD1單株抗體治療神經母細胞瘤

Translated title of the contribution: Combination of anti-GD2 monoclonal antibody with anti-PD1 for neuroblastoma treatment張凱珽, 2023, 61 p.

Research output: Types of Thesis › Master's thesis

Current Challenges of Asian National Children's Cancer Study Groups on Behalf of Asian Pediatric Hematology and Oncology Group

Li, C. K., Kurkure, P., Arora, R. S., Chen, B. W., Kirgizov, K., Okamoto, Y., Seksarn, P., Tang, Y., Yoo, K. H., Agarwal, B., Chan, G. C. F., Dalvi, R., Hori, H., Khan, M. S., Yu, A. & Nakagawara, A., 01 09 2023, In: JCO global oncology. 9, e2300153.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

4 Scopus citations

Detection of cytotoxins by sandwich-ELISA for discrimination of cobra envenomation and indication of necrotic severity

Liu, C. C., Chou, Y. S., Wu, C. J., Hsieh, C. H., Hsiao, Y. C., Chu, L. J., Ouyang, C. H., Lin, C. C., Liaw, G. W. & Chen, C. K., 01 07 2023, In: International Journal of Biological Macromolecules. 242, Pt 2, p. 124969 124969.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Differential Effects of ABCG5/G8 Gene Region Variants on Lipid Profile, Blood Pressure Status, and Gallstone Disease History in Taiwan

Teng, M. S., Yeh, K. H., Hsu, L. A., Chou, H. H., Er, L. K., Wu, S. & Ko, Y. L., 20 03 2023, In: Genes. 14, 3, 754.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

6 Scopus citations

Open Access

13 Scopus citations

Exploration of EVs membrane proteins as novel salivary biomarkers for early detection of OSCC

Chu, L.-C. J., Chu, L.-C. J., Yen, S.-Y., Tsai, C.-R., Chiang, W.-F., Chieh, C.-Y., Chang, K.-P. & Yu, J.-S., 2023.

Research output: Contribution to conference › Proceeding

Globo H ceramide is an independent prognostic marker for gallbladder cancer

Huang, Y.-M., Yu, A.-T., Yu, J., Wu, C.-E., 葉俊男, 洪榮堂, 洪再賢 & 李健瑋, 10 2023, In: American Journal of Cancer Research. 13, 10, p. 4811 - 4821

Research output: Contribution to journal › Journal Article › peer-review

Graduate Institute of Biomedical Sciences

Research output

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