Graduate Institute of Biomedical Sciences

2025

A genetic basis of mitochondrial DNAJA3 in nonalcoholic steatohepatitis-related hepatocellular carcinoma

Chang, C. W., Chen, Y. S., Huang, C. H., Lin, C. H., Ng, W. V., Chu, L. J., Trépo, E., Zucman-Rossi, J., Siao, K., Maher, J. J., Chiew, M. Y., Chou, C. H., Huang, H. D., Teo, W. H., Lee, I. S., Lo, J. F. & Wang, X. W., 01 01 2025, In: Hepatology. 81, 1, p. 60-76 17 p.

Research output: Contribution to journal › Journal Article › peer-review

Baseline serum EV-miR-1-3p as a protective factor and biomarker for hepatocellular carcinoma development after HCV eradication

Teng, W., Ku, W. T., Lin, P. T., Chen, G. T., Chu, L. C. J., Liu, H., Lin, Y. C. & Lin, C. Y., 12 2025, In: Journal of Translational Medicine. 23, 1, 722.

Research output: Contribution to journal › Journal Article › peer-review

Chemical modulation of Akt signaling enhances spinal cord regeneration in zebrafish

Shen, Y. J., Chen, H. Y., Chang, C. W., Huang, Y. C. & Cheng, Y. C., 01 01 2025, In: Brain Research. 1846, p. 149248 149248.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Empagliflozin Reduces High Glucose-Induced Cardiomyopathy in hiPSC-Derived Cardiomyocytes: Glucose-induced Lipotoxicity in hiPSC-Derived Cardiomyocytes

Tsai, H. H., Hsiao, F. C., Yu, A. L., Juang, J. H., Yu, J. & Chu, P. H., 04 2025, In: Stem Cell Reviews and Reports. 21, 3, p. 849-858 10 p.

Research output: Contribution to journal › Journal Article › peer-review

Enhancing retention and quality of tissue stromal vascular fraction graft with globo H ceramide

Cheng, J. Y., Cheng, H. Y., Hung, J. T., Restrepo, G. M., Chiou, S. P., Shih, L. Y., Yu, A. L., Kao, H. K., Yu, J. & Wei, F. C., 23 06 2025, In: Stem Cell Research and Therapy. 16, 1, p. 317 317.

Research output: Contribution to journal › Journal Article › peer-review

Extracellular vesicles from fifth-stage larval Angiostrongylus cantonensis upregulate cholesterol biosynthesis and suppress NLRP2-associated inflammatory responses in mouse astrocytes

Cheng, C. J., Wang, L. C., Chu, L. J., Chen, K. Y., Huang, C. Y., Lan, K. L. & Huang, K. Y., 21 01 2025, In: mSystems. 10, 1, p. e0101424

Research output: Contribution to journal › Journal Article › peer-review

Open Access

HBx mutant-regulated RPL13AP25 mediates suboptimal virological response to entecavir and HCC progression

Lin, Y. H., Lai, M. W., Chu, Y. D., Lin, K. H., Hsu, C. W., Chien, R. N., Chuang, P. H., Lin, C. L. & Yeh, C. T., 21 06 2025, In: Cancer Cell International. 25, 1, p. 223 223.

Research output: Contribution to journal › Journal Article › peer-review

Identifying the risk of Kawasaki disease based solely on routine blood test features through novel construction of machine learning models

Yang, T. H., Huang, Y. H., Lee, Y. H., Lai, J. N., Chen, K. D., Guo, M. M. H., Pan, Y., Chen, C. Y., Wu, W. S. & Kuo, H. C., 01 2025, In: Computational and Structural Biotechnology Journal. 27, p. 2832-2842 11 p.

Research output: Contribution to journal › Journal Article › peer-review

Immunomodulatory roles of autophagic flux and IFIT in human ectocervical cells upon Trichomonas vaginalis infection

Liu, C. C., Chu, L. J., Yeh, Y. M., Lin, H. C., Chen, L. C., Huang, C. Y., Chiu, S. F., Cheng, F. W., Lin, W. N. & Huang, K. Y., 16 05 2025, In: International Immunopharmacology. 155, 114643.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

Integrated multi-omics analyses of oral squamous cell carcinoma reveal precision patient stratification and personalized treatment strategies

Wu, C. S., Li, H. P., Hsieh, C. H., Lin, Y. T., Yi-Feng Chang, I., Chung, A. K., Huang, Y., Ueng, S. H., Hsiao, Y. C., Chien, K. Y., Luo, J. D., Chen, C. H., Liao, W. C., Hung, J. L., Yuan, S. N., OuYang, C. N., Chiang, W. F., Chien, C. Y., Chuang, H. C. & Chu, L. J. & 10 others, Liu, H., Yang, C. Y., Robles, A. I., Rodriguez, H., Lin, H. H., Yang, H. Y., Hsueh, C., Chang, K. P., Yu, J. S. & Chang, Y. S., 01 04 2025, In: Cancer Letters. 614, p. 217482 217482.

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

Plasma POSTN Derived From Bile Proteome Is a Promising Biomarker for Cholangiocarcinoma With Efficacy Comparable and Complementary to CA19.9

Chu, L. J., Tsai, C. J., Chien, C. C., Hsiao, Y. C., Yu, J. S., Tsai, J. Y. & Yeh, T. S., 2025, (Accepted/In press) In: United European Gastroenterology Journal.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

ST3GAL1 regulates cancer cell migration through crosstalk between EGFR and neuropilin-1 signaling

Fan, T. C., Yeo, H. L., Hung, T. H., Chang, N. C., Tang, Y. H., Yu, J., Chen, S. H. & Yu, A. L., 04 2025, In: Journal of Biological Chemistry. 301, 4, p. 108368 108368.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Stimulation of dorsal root ganglion with low-intensity focused ultrasound ameliorates pain responses through the GABA inhibitory pathway

Lin, Y. T., Chen, K. T., Hsu, C. C., Liu, H. L., Jiang, Y. T., Ho, C. W., Chen, J. C., Li, H. Y., Weng, C. C. & Hsu, P. H., 15 01 2025, In: Life Sciences. 361, 123323.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Trichomonas vaginalis extracellular vesicles activate the NLRP3 inflammasome and TLR3-mediated inflammatory cascades in host cells

Huang, C. Y., Chiu, S. F., Chu, L. J., Yeh, Y. M., Huang, P. J., Lan, K. L., Tsai, Y. L., Liu, C. C., Chen, C. F. F., Lin, W. N. & Huang, K. Y., 06 2025, In: PLoS Pathogens. 21, 6, p. e1013216 e1013216.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

Tumor-Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion

Cheng, J. Y., Tsai, H. H., Hung, J. T., Hung, T. H., Lin, C. C., Lee, C. W., Lo, Z. C., Huang, J. R., Chiou, S. P., Huang, Y., Chen, S. H., Yeh, C. N., Yu, J. & Yu, A. L., 2025, (Accepted/In press) In: Advanced Science.

Research output: Contribution to journal › Journal Article › peer-review

2024

Benchmarking 13 tools for mutational signature attribution, including a new and improved algorithm

Jiang, N., Wu, Y. & Rozen, S. G., 22 11 2024, In: Briefings in Bioinformatics. 26, 1, bbaf042.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

Clinical validation of a saliva-based matrix metalloproteinase-1 rapid strip test for detection of oral cavity cancer

Chu, L. J., Chang, Y. T., Chien, C. Y., Chung, H. C., Wu, S. F., Chen, C. J., Liu, Y. C., Liao, W. C., Chen, C. H., Chiang, W. F., Chang, K.-P., Wang, J. S. & Yu, J. S., 02 2024, In: Biomedical Journal. 47, 1, p. 100594 100594.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

5 Scopus citations

Detection of toxigenic M1_UK lineage group A Streptococcus clones in Taiwan

Chiang-Ni, C., Hsu, C. Y., Yeh, Y. H., Chi, C. Y., Wang, S., Tsai, P. J. & Chiu, C. H., 04 2024, In: Journal of Microbiology, Immunology and Infection. 57, 2, p. 269-277 9 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

9 Scopus citations

Development and optimization of a DNA aptamer to delay β-bungarotoxin-induced lethality in a rodent model

Liu, C. C., Hsiao, Y. C., Lai, W. J., Chiou, C. C., Chu, L. J., Lin, Y. T., Liu, J. C. & Yu, J. S., 06 2024, In: International Journal of Biological Macromolecules. 270, Pt 2, p. 132240 132240.

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

Development of antibody-detection ELISA based on beta-bungarotoxin for evaluation of the neutralization potency of equine plasma against Bungarus multicinctus in Taiwan

Liu, C. C., Lin, C. C., Liou, M. H., Hsiao, Y. C., Chu, L. J., Wang, P. J., Liu, C. H., Wang, C. Y., Chen, C. H. & Yu, J. S., 03 2024, In: International Journal of Biological Macromolecules. 262, Pt 2, p. 130080 130080.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Dtx2 Deficiency Induces Ependymo-Radial Glial Cell Proliferation and Improves Spinal Cord Motor Function Recovery

Chen, H. Y., Huang, Y. C., Yeh, T. H., Chang, C. W., Shen, Y. J., Chen, Y. C., Sun, M. Q. & Cheng, Y. C., 01 10 2024, In: Stem Cells and Development. 33, 19-20, p. 540-550 11 p.

Research output: Contribution to journal › Journal Article › peer-review

Effective suppression of tumor growth and hepatic metastasis of neuroblastoma by NKT-stimulatory phenyl glycolipid

Wu, T. N., Hung, J. T., Hung, T. H., Wang, Y. H., Wu, J. C. & Yu, A. L., 08 2024, In: Biomedicine and Pharmacotherapy. 177, p. 117040 117040.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

4 Scopus citations

Genetic diversity, biofilm formation, and Vancomycin resistance of clinical Clostridium innocuum isolates

Chiang-Ni, C., Huang, J. Y., Hsu, C. Y., Lo, Y. C., Chen, Y. Y. M., Lai, C. H. & Chiu, C. H., 18 09 2024, In: BMC Microbiology. 24, 1, p. 353 353.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

1 Scopus citations

High expression of embryonic stem cell marker SSEA3 confers poor prognosis and promotes epithelial mesenchymal transition in hepatocellular carcinoma

Hung, T. H., Huang, Y., Yeh, C. T., Yeh, C. N., Yu, J., Lin, C. C., Chiou, S. P., Chiang, P. Y., Hung, J. T. & Yu, A. L., 04 2024, In: Biomedical Journal. 47, 2, p. 100612 100612.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

6 Scopus citations

Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus

Lin, Y.-T., Wu, K. H., Jhang, J. J., Jhang, J. L., Yu, Z., Tsai, S. C., Chen, J. C., Hsu, P. H. & Li, H. Y., 03 2024, In: Clinical Nutrition. 43, 3, p. 603-619 17 p.

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Identification of endothelial cell protein c receptor by urinary proteomics as a novel prognostic marker in non-recovery kidney injury

Yang, C.-W., Yu, J.-S., Chen, Y.-T., Chu, L. J., Chu, P.-H., Chang, C.-H., Chen, H.-W., Chen, Y.-C., Lee, C.-C. & Fan, P.-C., 02 2024, In: International Journal of Molecular Sciences. 25, 5, p. 2783 - 2796

Research output: Contribution to journal › Journal Article › peer-review

Identification of Endothelial Cell Protein C Receptor by Urinary Proteomics as Novel Prognostic Marker in Non-Recovery Kidney Injury

Chang, C. H., Lee, C. C., Chen, Y. C., Fan, P. C., Chu, P. H., Chu, L. J., Yu, J. S., Chen, H. W., Yang, C. W. & Chen, Y. T., 28 02 2024, In: International Journal of Molecular Sciences. 25, 5, 2783.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages

Onyishi, C. U., Jeon, Y., Fejer, G., Mukhopadhyay, S., Gordon, S. & May, R. C., 06 2024, In: European Journal of Immunology. 54, 6, p. e2350771 2350771.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

4 Scopus citations

Molecular profiling reveals novel therapeutic targets and clonal evolution in ovarian clear cell carcinoma

Chao, A., Huang, C. Y., Yu, W., Lin, C. Y., Lin, H., Chao, A. S., Lin, C. T., Chou, H. H., Huang, K. G., Huang, H. J., Chang, T. C., Rozen, S. G., Wu, R. C. & Lai, C. H., 14 11 2024, In: BMC Cancer. 24, 1, p. 1403 1403.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

4 Scopus citations

Novel Anti-Viral Properties of the Herbal Extract of Davallia mariesii against Influenza A Virus

Chen, Y.-L., Chao, P.-Y., Hsieh, C.-F., Hsieh, P.-W. & Horng, J.-T., 28 03 2024, In: Viruses. 16, 4, 523.

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions

Pan, Y. R., Lai, J. C. Y., Huang, W. K., Peng, P. H., Jung, S. M., Lin, S. H., Chen, C. P., Wu, C. E., Hung, T. H., Yu, A. L., Wu, K. J. & Yeh, C. N., 02 2024, In: Cancer Gene Therapy. 31, 2, p. 322-333 12 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

4 Scopus citations

Suppression of presynaptic corticostriatal glutamate activity attenuates L-dopa-induced dyskinesia in 6-OHDA-lesioned Parkinson's disease mice

Huang, Y. T., Chen, Y. W., Lin, T. Y. & Chen, J. C., 04 2024, In: Neurobiology of Disease. 193, p. 106452 106452.

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions

Hu, H.-C., Yu, S.-Y., Tsai, Y.-H., Hsieh, P.-W., Wang, H.-C., Chen, Y.-N., Chuang, Y.-T., Lee, M.-Y., Chang, H.-W., Hu, H.-C., Wu, Y.-C., Chang, F.-R., Szatmári, I. & Fülöp, F., 27 03 2024, In: Organic and Biomolecular Chemistry. 22, 13, p. 2620-2629 10 p.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Systematic Evaluation of Chromatographic Peak Quality for Targeted Mass Spectrometry via Variational Autoencoder

Yang, C., Hsiao, Y. C., Lee, C. C. & Yu, J. S., 02 2024, In: Analytical Chemistry. 96, 7, p. 2849 - 2856 8 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

Temporal and Spatial Variations in Zebrafish Hairy/E(spl) Gene Expression in Response to Mib1-Mediated Notch Signaling During Neurodevelopment

Chen, Y. C., Hsieh, F. Y., Chang, C. W., Sun, M. Q. & Cheng, Y. C., 23 08 2024, In: International Journal of Molecular Sciences. 25, 17, 9174.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

The novel role of LOC344887 in the enhancement of hepatocellular carcinoma progression via modulation of SHP1-regulated STAT3/HMGA2 signaling axis

Lin, Y. H., Chi, H.-C., Wu, M. H., Liao, C. J., Chen, C. Y., Huang, P. S., Huang, W. C., Wang, Y. W., Lin, T. K., Lai, M. W., Yeh, C. T. & Lin, K. H., 2024, In: International Journal of Biological Sciences. 20, 15, p. 6281-6296 16 p.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Unifying considerations and evidence of macrophage activation mosaicism through human CSF1R and M1/M2 genes

Orsenigo, F., Stewart, A., Hammer, C. P., Clarke, E., Simpkin, D., Attia, H., Rockall, T., Gordon, S. & Martinez, F. O., 25 06 2024, In: Cell Reports. 43, 6, p. 114352 114352.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

2 Scopus citations

2023

Current Challenges of Asian National Children's Cancer Study Groups on Behalf of Asian Pediatric Hematology and Oncology Group

Li, C. K., Kurkure, P., Arora, R. S., Chen, B. W., Kirgizov, K., Okamoto, Y., Seksarn, P., Tang, Y., Yoo, K. H., Agarwal, B., Chan, G. C. F., Dalvi, R., Hori, H., Khan, M. S., Yu, A. & Nakagawara, A., 01 09 2023, In: JCO global oncology. 9, e2300153.

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Detection of cytotoxins by sandwich-ELISA for discrimination of cobra envenomation and indication of necrotic severity

Liu, C. C., Chou, Y. S., Wu, C. J., Hsieh, C. H., Hsiao, Y. C., Chu, L. J., Ouyang, C. H., Lin, C. C., Liaw, G. W. & Chen, C. K., 01 07 2023, In: International Journal of Biological Macromolecules. 242, Pt 2, p. 124969 124969.

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Differential Effects of ABCG5/G8 Gene Region Variants on Lipid Profile, Blood Pressure Status, and Gallstone Disease History in Taiwan

Teng, M. S., Yeh, K. H., Hsu, L. A., Chou, H. H., Er, L. K., Wu, S. & Ko, Y. L., 20 03 2023, In: Genes. 14, 3, 754.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

6 Scopus citations

Etv5a Suppresses Neural Progenitor Cell Proliferation by Inhibiting sox2 Transcription

Shih, H. Y., Chen, H. Y., Huang, Y. C., Yeh, T. H., Chen, Y. C. & Cheng, Y. C., 09 2023, In: Stem Cells and Development. 32, 17-18, p. 524-538 15 p.

Research output: Contribution to journal › Journal Article › peer-review

Globo H ceramide is an independent prognostic marker for gallbladder cancer

Huang, Y.-M., Yu, A.-T., Yu, J., Wu, C.-E., 葉俊男, 洪榮堂, 洪再賢 & 李健瑋, 10 2023, In: American Journal of Cancer Research. 13, 10, p. 4811 - 4821

Research output: Contribution to journal › Journal Article › peer-review

HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease

Wang, H. L., Cheng, Y. C., Yeh, T. H., Liu, H. F., Weng, Y. H., Chen, R. S., Chen, Y. C., Lu, J. C., Hwang, T. L., Wei, K. C., Liu, Y. C., Wang, Y. T., Hsu, C. C., Chiu, T. J. & Chiu, C. C., 06 2023, In: Biochemical Pharmacology. 212, p. 115524 115524.

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

HeapMS: An Automatic Peak-Picking Pipeline for Targeted Proteomic Data Powered by 2D Heatmap Transformation and Convolutional Neural Networks

Lee, C. C., Lin, Y. C., Pan, T. Y., Yang, C. H., Li, P. H., Chen, S. Y., Gao, J. J., Yang, C., Chu, L. J., Huang, P. J., Yeh, Y. M., Tang, P., Chang, Y. S., Yu, J. S. & Hsiao, Y. C., 24 10 2023, In: Analytical Chemistry. 95, 42, p. 15486-15496 11 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

1 Scopus citations

Identification of the Time Period during Which BMP Signaling Regulates Proliferation of Neural Progenitor Cells in Zebrafish

Shih, H. Y., Chang, C. W., Chen, Y. C. & Cheng, Y. C., 15 01 2023, In: International Journal of Molecular Sciences. 24, 2, 1733.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

2 Scopus citations

Immunoprofiling of Equine Plasma against Deinagkistrodon acutus in Taiwan: Key to Understanding Differential Neutralization Potency in Immunized Horses

Wu, C. J., Liaw, G. W., Chen, C. K., Ouyang, C. H., Yang, Y. X., Chu, L. C., Hsiao, Y. C., Liu, C. H., Hsieh, W. C., Wang, C. Y., Liou, Y. S., Liu, C. C. & Hsieh, C. H., 09 01 2023, In: Tropical Medicine and Infectious Disease. 8, 1, 51.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

4 Scopus citations

Impact of diagnostic and end-of-induction Curie scores with tandem high-dose chemotherapy and autologous transplants for metastatic high-risk neuroblastoma: A report from the Children's Oncology Group

Streby, K. A., Parisi, M. T., Shulkin, B. L., LaBarre, B., Bagatell, R., Diller, L., Grupp, S. A., Matthay, K. K., Voss, S. D., Yu, A. L., London, W. B., Park, J. R., Yanik, G. A. & Naranjo, A., 08 2023, In: Pediatric Blood and Cancer. 70, 8, p. e30418 e30418.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

4 Scopus citations

KIR/KIR-ligand genotypes and clinical outcomes following chemoimmunotherapy in patients with relapsed or refractory neuroblastoma: A report from the Children's Oncology Group

Erbe, A. K., Diccianni, M. B., Mody, R., Naranjo, A., Zhang, F. F., Birstler, J., Kim, K., Feils, A. S., Hung, J. T., London, W. B., Shulkin, B. L., Mathew, V., Parisi, M. T., Servaes, S., Asgharzadeh, S., Maris, J. M., Park, J., Yu, A. L., Sondel, P. M. & Bagatell, R., 23 02 2023, In: Journal for ImmunoTherapy of Cancer. 11, 2, e006530.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

8 Scopus citations

Mifepristone inhibits hepatoma growth by enhancing the GR-HSP60-survivin interaction to facilitate survivin degradation

Translated title of the contribution: A beautiful fallacy? - Breeding of albatross on Taiwan's outer islands]Huang, Y. H., Lin, K. H., Lai, M. W. & Yeh, C. T., 2023, In: Journal of Cancer. 14, 16, p. 3066-3077

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

Mucin 4 Confers Gemcitabine Resistance and an Unfavorable Prognosis in Patients with Cholangiocarcinoma via AKT Activation

Pan, Y. R., Wu, C. E., Jung, S. M., Huang, S. C., Lin, S. H., Chou, W. C., Chang, Y. C., Chen, M. H., Hung, T. H., Yu, A. L., Huang, W. K. & Yeh, C. N., 2023, In: International Journal of Biological Sciences. 19, 9, p. 2772-2786 15 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

5 Scopus citations

Graduate Institute of Biomedical Sciences

Research output

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