Personal profile
Courses
- Pharmacodynamic Evaluation of Chinese Herbal Drugs
- Pharmacodynamic Evaluation of Chinese Herbal Drugs Laboratory
- Natural products in cancer and precision medicine
- Structural biology for natural product-based drug discovery
- Seminar
Research interests
- Nucleic acid structures and functions
- Nucleic acid therapeutics
- Natural product-inspired ligands
- DNA repair modulators and precision oncology
- Neurodegeneration & repeat expansion disorders
Education
Courses
Structural biology for natural product-based drug discovery
Natural products in cancer and precision medicine
External positions
Assistant Research Fellow, Chang Gung Memorial Hospital
Keywords
- X-ray crystallography
- Structure-based Drug Development
- Natural Products
- Nucleic Acid Chemical Biology
- Cancer
- Neurological Diseases
Laboratory
- Biomolecular Structures and Drug Development Laboratory
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 4 Quality Education -
SDG 9 Industry, Innovation, and Infrastructure -
SDG 17 Partnerships for the Goals
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Collaborations and top research areas from the last five years
Projects
- 2 Active
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Biophysical, Structural, and Biochemical Investigations of Natural Compounds Targeting Non-Canonical Dna Structures for Neurological Disease Therapeutic Development
Satange, R. (PI) & Wang, T. H. (CoPI)
01/11/25 → 31/10/26
Project: National Science and Technology Council › National Science and Technology Council Academic Grants
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補骨脂寧抗老化機轉及神經保護活性之研究
王東弘 (PI), Chiu, C.-C. (CoPI), 楊世駿 (CoPI), Chen, C.-C. (CoPI) & Satange, R. (CoPI)
01/08/23 → 31/07/26
Project: National Science and Technology Council › National Science and Technology Council Academic Grants
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Structural and Functional Insights into Targeting GCCG Sites in the EGFR Promoter by Two DNA Intercalators to Inhibit Breast Cancer Metastasis
Chang, C.-C., Li, H.-J., Satange, R., Lin, S.-M., Chen, T.-L., Lin, C.-C., Neidle, S. & Hou, M.-H., 27 03 2025, In: Journal of Medicinal Chemistry. 68, 6, p. 6601-6615 15 p.Research output: Contribution to journal › Journal Article › peer-review
1 Scopus citations -
The role of water in mediating DNA structures with epigenetic modifications, higher-order conformations and drug–DNA interactions
Satange, R. & Hou, M.-H., 08 05 2025, In: RSC Chemical Biology. 6, 5, p. 699-720 22 p.Research output: Contribution to journal › Review article › peer-review
Open Access6 Scopus citations -
Antiviral drug development by targeting RNA binding site, oligomerization and nuclear export of influenza nucleoprotein
Panthi, S., Hong, J.-Y., Satange, R., Yu, C.-C., Li, L.-Y. & Hou, M.-H., 12 2024, In: International Journal of Biological Macromolecules.Research output: Contribution to journal › Journal Article › peer-review
6 Scopus citations -
Structural basis of water-mediated cis Watson–Crick/Hoogsteen base-pair formation in non-CpG methylation
Lin, S. M., Huang, H. T., Fang, P. J., Chang, C. F., Satange, R., Chang, C. K., Chou, S. H., Neidle, S. & Hou, M. H., 12 08 2024, In: Nucleic Acids Research. 52, 14, p. 8566-8579 14 p.Research output: Contribution to journal › Journal Article › peer-review
Open Access1 Scopus citations -
Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects
Huang, S. C., Chen, C. W., Satange, R., Hsieh, C. C., Chang, C. C., Wang, S. C., Peng, C. L., Chen, T. L., Chiang, M. H., Horng, Y. C. & Hou, M. H., 27 08 2024, In: Nucleic Acids Research. 52, 15, p. 9303-9316 14 p.Research output: Contribution to journal › Journal Article › peer-review
Open Access3 Scopus citations