Scott Charles Schuyler

2024

Suppressing Anaphase-Promoting Complex/Cyclosome–Cell Division Cycle 20 Activity to Enhance the Effectiveness of Anti-Cancer Drugs That Induce Multipolar Mitotic Spindles

Schuyler, S. C., Chen, H. Y. & Chang, K.-P., 07 06 2024, In: International Journal of Molecular Sciences. 25, 12, 6329.

Research output: Contribution to journal › Review article › peer-review

Open Access

2023

Editorial: Chromosome bi-orientation, tension and the spindle-assembly checkpoint

Schuyler, S. C., 2023, In: Frontiers in Cell and Developmental Biology. 11, p. 1245368 1245368.

Research output: Contribution to journal › Journal Editorial

Open Access

Podocalyxin-Like Protein 1 Regulates Pluripotency through the Cholesterol Biosynthesis Pathway

Chen, W. J., Huang, W. K., Pather, S. R., Chang, W. F., Sung, L. Y., Wu, H. C., Liao, M. Y., Lee, C. C., Wu, H. H., Wu, C. Y., Liao, K. S., Lin, C. Y., Yang, S. C., Lin, H., Lai, P. L., Ng, C. H., Hu, C. M., Chen, I. C., Chuang, C. H. & Lai, C. Y. & 6 others, Lin, P. Y., Lee, Y. C., Schuyler, S. C., Schambach, A., Lu, F. L. & Lu, J., 04 01 2023, In: Advanced Science. 10, 1, p. e2205451 2205451.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

5 Scopus citations

2022

Development of a Chemical Cocktail That Rescues Mouse Brain Demyelination in a Cuprizone-Induced Model

Lai, P. L., Ng, C. H., Wu, C. H., Lai, C. Y., Schuyler, S. C., Wang, V., Lin, H., Lee, Y. C., Chuang, M. H., Yang, C. H., Chen, W. J., Huang, H. C. & Lu, J., 01 04 2022, In: Cells. 11, 7, 1091.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

用於推定A型流感病毒感染的嚴重性的方法

Translated title of the contribution: Method for estimating severity of influenza A virus infectionSchuyler, S. C. (Inventor), Lin, S.-J. (Inventor), TSAI, C.-H. (Inventor) & LIN, C.-N. (Inventor), 01 04 2022, IPC No. G01N 33/53(2006.01); G01N 33/569(2006.01); G01N 30/02(2006.01)

Research output: Patent

用於推定A型流感病毒感染的嚴重性的方法

Translated title of the contribution: Method for estimating severity of influenza A virus infectionSchuyler, S. C. (Inventor), Lin, S.-J. (Inventor), TSAI, C.-H. (Inventor) & LIN, C.-N. (Inventor), 21 05 2022, IPC No. G01N 33/53(2006.01); G01N 30/02(2006.01); G01N 33/569(2006.01), Patent No. I765350

Research output: Patent

2021

Comparative analyses of single-cell transcriptomic profiles between in vitro totipotent blastomere-like cells and in vivo early mouse embryonic cells

Lin, P. Y., Yang, D., Chuang, C. H., Lin, H., Chen, W. J., Chen, C. Y., Chuang, T. J., Lai, C. Y., Li, L. Y., Schuyler, S. C., Lu, F. L., Liu, Y. C. & Lu, J., 11 2021, In: Cells. 10, 11, 3111.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

6 Scopus citations

Protein Complexes Form a Basis for Complex Hybrid Incompatibility

Swamy, K. B. S., Schuyler, S. C. & Leu, J. Y., 09 02 2021, In: Frontiers in Genetics. 12, 609766.

Research output: Contribution to journal › Review article › peer-review

Open Access

13 Scopus citations

Using budding yeast to identify molecules that block cancer cell ‘mitotic slippage’ only in the presence of mitotic poisons

Schuyler, S. C. & Chen, H. Y., 01 08 2021, In: International Journal of Molecular Sciences. 22, 15, 7985.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

2020

Combination Vaccination With Tetanus Toxoid and Enhanced Tumor-Cell Based Vaccine Against Cervical Cancer in a Mouse Model

Alson, D., Schuyler, S. C., Yan, B. X., Samimuthu, K. & Qiu, J. T., 27 05 2020, In: Frontiers in Immunology. 11, 927.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

6 Scopus citations

Deletion of budding yeast mad2 suppresses clone-to-clone differences in artificial linear chromosome copy numbers and gives rise to higher retention rates

Schuyler, S. C., Wang, L. I., Ding, Y. S., Lee, Y. C. & Chen, H. Y., 10 2020, In: Microorganisms. 8, 10, p. 1-15 15 p., 1495.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

2019

Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2

Yang, S. C., Liu, J. J., Wang, C. K., Lin, Y. T., Tsai, S. Y., Chen, W. J., Huang, W. K., Tu, P. W. A., Lin, Y. C., Chang, C. F., Cheng, C. L., Lin, H., Lai, C. Y., Lin, C. Y., Lee, Y. H., Chiu, Y. C., Hsu, C. C., Hsu, S. C., Hsiao, M. & Schuyler, S. C. & 2 others, Lu, F. L. & Lu, J., 01 09 2019, In: FASEB Journal. 33, 9, p. 10577-10592 16 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

6 Scopus citations

Effect of multiple vaccinations with tumor cell-based vaccine with codon-modified GM-CSF on tumor growth in a mouse model

Qiu, J. T., Alson, D., Lee, T. H., Tsai, C. C., Yu, T. W., Chen, Y. S., Cheng, Y. F., Lin, C. C. & Schuyler, S. C., 03 2019, In: Cancers. 11, 3, 368.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

9 Scopus citations

2018

Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison

Schuyler, S. C., Wu, Y. F. O., Chen, H. Y., Ding, Y. S., Lin, C. J., Chu, Y. T., Chen, T. C., Liao, L., Tsai, W. W., Huang, A., Wang, L. I., Liao, T. W., Jhuo, J. H. & Cheng, V., 06 2018, In: PLoS ONE. 13, 6, e0198930.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

6 Scopus citations

2016

The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase

Wu, S. Y., Kuan, V. J. W., Tzeng, Y. W., Schuyler, S. C. & Juang, Y. L., 01 06 2016, In: Fungal Genetics and Biology. 91, p. 6-19 14 p.

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

2015

Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells

Wu, C. C., Wu, H. J., Wang, C. H., Lin, C. H., Hsu, S. C., Chen, Y. R., Hsiao, M., Schuyler, S. C., Leigh Lu, F., Ma, N. & Lu, J., 15 04 2015, In: Cell Cycle. 14, 8, p. 1207-1217 11 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

15 Scopus citations

2014

A peptide inhibitor of APC-Cdc20 based on the Cdc20 Mad2-binding motif can directly bind to the APC.

Liao, Y., Wu, Y., Jhuo, J. & Schuyler, S. C., 2014, In: Molecular Biology of the Cell. 25

Research output: Contribution to journal › Journal Article › peer-review

Budding yeast YBR296C-A encodes a protein that can inhibit APC-Cdc20 in vitro and contains amino acid motifs conserved with human p31comet

Tsai, W., Wu, Y., Huang, A., Wang, L. & Schuyler, S. C., 2014, In: Molecular Biology of the Cell. 25

Research output: Contribution to journal › Journal Article › peer-review

CCL5/RANTES is important for inducing osteogenesis of human mesenchymal stem cells and is regulated by dexamethasone

Liu, Y. C., Kao, Y. T., Huang, W. K., Lin, K. Y., Wu, S. C., Hsu, S. C., Schuyler, S. C., Li, L. Y., Lu, F. L. & Lu, J., 2014, In: BioScience Trends. 8, 3, p. 138-143 6 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

35 Scopus citations

Expression in vivo of peptide inhibitors of APC-Cdc20 reduces growth rate.

Chen, H., Wu, Y. & Schuyler, S. C., 2014, In: Molecular Biology of the Cell. 25

Research output: Contribution to journal › Journal Article › peer-review

Functional Impact of RNA editing and ADARs on regulation of gene expression: Perspectives from deep sequencing studies

Liu, H., Ma, C. P., Chen, Y. T., Schuyler, S. C., Chang, K. P. & Tan, B. C. M., 19 08 2014, In: Cell and Bioscience. 4, 1, p. 1-7 7 p., 44.

Research output: Contribution to journal › Review article › peer-review

Open Access

20 Scopus citations

Investigating spindle checkpoint component expression levels in nasopharyngeal carcinoma tissue culture cells.

Chu, Y. & Schuyler, S. C., 2014, In: Molecular Biology of the Cell. 25

Research output: Contribution to journal › Journal Article › peer-review

MiR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation

Huang, H. N., Chen, S. Y., Hwang, S. M., Yu, C. C., Su, M. W., Mai, W., Wang, H. W., Cheng, W. C., Schuyler, S. C., Ma, N., Lu, F. L. & Lu, J., 03 2014, In: Stem Cell Research. 12, 2, p. 338-353 16 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

46 Scopus citations

The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase

Wu, S., Kuan, V. J., Tseng, Y., Schuyler, S. C. & Juang, Y., 2014, In: Molecular Biology of the Cell. 25

Research output: Contribution to journal › Journal Article › peer-review

The Hsp90-dependent proteome is conserved and enriched for hub proteins with high levels of protein-protein connectivity

Gopinath, R. K., You, S. T., Chien, K. Y., Swamy, K. B. S., Yu, J. S., Schuyler, S. C. & Leu, J. Y., 10 2014, In: Genome Biology and Evolution. 6, 10, p. 2851-2865 15 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

24 Scopus citations

2013

Array-Based High-Throughput Screening UNIT 5C.3 in Mouse Embryonic Stem Cells with shRNAs

Wang, C. H., Ma, N., Lin, Y. T., Wu, C. C., Wu, H. J., Yu, C. C., Hsiao, M., Lu, F. L., Schuyler, S. C. & Lu, J., 08 2013, In: Current protocols in stem cell biology. 1, SUPPL.26, p. 5C.3.1-5C.3.19

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Cdc20 (Cell Division Cycle 20) Mad2 (Mitotic Arrest-Deficient 2)-binding motif amino acid residues necessary for Anaphase-Promoting Complex (APC)

Wu, Y.-F. & Schuyler, S. C., 2013, In: Molecular Biology of the Cell. 24

Research output: Contribution to journal › Journal Article › peer-review

Dual regulation of the S phase B-type cyclin Clb6 in late G1 phase to prevent premature entry into S phase

Kuan, V., Wu, S.-Y., Tzeng, Y.-W., Juang, Y.-L. & Schuyler, S. C., 2013, In: Molecular Biology of the Cell. 24

Research output: Contribution to journal › Journal Article › peer-review

Loss of Mad2 suppresses clonal variation of yeast artificial chromosome copy number and retention rate

Ding, Y.-S., Wang, L.-I., Lee, Y.-C. & Schuyler, S. C., 2013, In: Molecular Biology of the Cell. 24

Research output: Contribution to journal › Journal Article › peer-review

Sonic hedgehog antagonists induce cell death in acute myeloid leukemia cells with the presence of lipopolysaccharides, tumor necrosis factor-α, or interferons

Lu, F. L., Yu, C. C., Chiu, H. H., Liu, H. E., Chen, S. Y., Lin, S., Goh, T. Y., Hsu, H. C., Chien, C. H., Wu, H. C., Chen, M. S., Schuyler, S. C., Hsieh, W. S., Wu, M. H. & Lu, J., 08 2013, In: Investigational New Drugs. 31, 4, p. 823-832 10 p.

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

出席「ASCB 53rd Annual Meeting」報告

Schuyler, S. C., 2013.

Research output: Contribution to conference › International Conference Report

2012

Measuring aneuploidy by counting yeast artificial chromosomes in mad2 spindle checkpoint mutant cells.

Schuyler, S. C., Ding, Y.-S., Lee, Y.-C., Wang, L.-I. & Lai, P., 2012, In: Molecular Biology of the Cell. 23

Research output: Contribution to journal › Journal Article › peer-review

The Mad1-Mad2 balancing act - A damaged spindle checkpoint in chromosome instability and cancer

Schuyler, S. C., Wu, Y. F. & Kuan, V. J. W., 2012, In: Journal of Cell Science. 125, 18, p. 4197-4206 10 p.

Research output: Contribution to journal › Comment/debate

Open Access

52 Scopus citations

The Mad2-binding motif in Cdc20 contributes to activation of the Anaphase-Promoting Complex/Cyclosome.

Wu, Y.-F. & Schuyler, S. C., 2012, In: Molecular Biology of the Cell. 23

Research output: Contribution to journal › Journal Article › peer-review

Yeast S-phase B-type cyclin Clb6 is a substrate in late G1 for the cyclin-dependent kinases Cdc28 and Pho85

Kuan, V.J.-W., Wang, W., Tseng, Y.-W., Wu, S.-Y., Juang, Y.-L. & Schuyler, S. C., 2012, In: Molecular Biology of the Cell. 23

Research output: Contribution to journal › Journal Article › peer-review

出席「The American Society for Cell Biology (ASCB) 52nd annual meeting」報告

Schuyler, S. C., 2012.

Research output: Contribution to conference › International Conference Report

2011

Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase

Tzeng, Y. W., Huang, J. N., Schuyler, S. C., Wu, C. H. & Juang, Y. L., 10 2011, In: Fungal Genetics and Biology. 48, 10, p. 966-978 13 p.

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity

Wu, Y. P., Chang, C. M., Hung, C. Y., Tsai, M. C., Schuyler, S. C. & Wang, R. Y. L., 2011, In: Virology Journal. 8, 128.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

56 Scopus citations

Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity (vol 8, 128, 2011)

Wu, Y.-P., Chang, C.-M., Hung, C.-Y., Tsai, M.-C., Schuyler, S. C. & Wang, R.Y.-L., 2011, In: Virology Journal. 8

Research output: Contribution to journal › Journal Article › peer-review

Reduced Mad2 expression keeps relaxed kinetochores from arresting budding yeast in mitosis

Barnhart, E. L., Dorer, R. K., Murray, A. W. & Schuyler, S. C., 15 07 2011, In: Molecular Biology of the Cell. 22, 14, p. 2448-2457 10 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

18 Scopus citations

Teaching English Scientific Writing at the Undergraduate Level in Taiwan.

Schuyler, S. C., 2011, In: Molecular Biology of the Cell. 22

Research output: Contribution to journal › Journal Article › peer-review

出席「ASCB Annual Meeting」報告

Schuyler, S. C., 2011.

Research output: Contribution to conference › International Conference Report

2010

出席「ASCB 50th Annual Meeting」報告

Schuyler, S. C., 2010.

Research output: Contribution to conference › International Conference Report

2009

An in vitro assay for Cdc20-dependent mitotic anaphase-promoting complex activity from budding yeast

Schuyler, S. C. & Murray, A. W., 2009, Mitosis: Methods and Protocols. McAinsh, A. (ed.). p. 271-285 15 p. (Methods in Molecular Biology; vol. 545).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Scopus citations

2004

The Differential Roles of Budding Yeast Tem1p, Cdc15p, and Bub2p Protein Dynamics in Mitotic Exit

Molk, J. N., Schuyler, S. C., Liu, J. Y., Evans, J. G., Salmon, E. D., Pellman, D. & Bloom, K., 04 2004, In: Molecular Biology of the Cell. 15, 4, p. 1519-1532 14 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

79 Scopus citations

2003

The molecular function of Ase1p: Evidence for a MAP-dependent midzone-specific spindle matrix

Schuyler, S. C., Liu, J. Y. & Pellman, D., 17 02 2003, In: Journal of Cell Biology. 160, 4, p. 517-528 12 p.

Research output: Contribution to journal › Journal Article › peer-review

Open Access

172 Scopus citations

2002

Analysis of the size and shape of protein complexes from yeast

Schuyler, S. C. & Pellman, D., 2002, In: Methods in Enzymology. 351, p. 150-168 19 p.

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

2001

Microtubule "plus-end-tracking proteins": The end is just the beginning

Schuyler, S. C. & Pellman, D., 18 05 2001, In: Cell. 105, 4, p. 421-424 4 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

327 Scopus citations

Search, capture and signal: Games microtubules and centrosomes play

Schuyler, S. C. & Pellman, D., 2001, In: Journal of Cell Science. 114, 2, p. 247-255 9 p.

Research output: Contribution to journal › Comment/debate

108 Scopus citations

2000

Positioning of the mitotic spindle by a cortical-microtubule capture mechanism

Lee, L., Tirnauer, J. S., Li, J., Schuyler, S. C., Liu, J. Y. & Pellman, D., 24 03 2000, In: Science. 287, 5461, p. 2260-2262 3 p.

Research output: Contribution to journal › Journal Article › peer-review

243 Scopus citations

Scott Charles Schuyler

Research output

Search results