放射性碘-131標幟PARP抑制劑於三陰性乳癌治療效益評估

Project: Atomic Energy CouncilAtomic Energy Council Commission Research

Project Details

Abstract

In the past decade, cancer has been the leading cause of death for Taiwanese people, and breast cancer is the most diagnosed cancer among women in our country. For the treatment of breast cancer, usually different targeted drugs or compounds are prescribed depending on the expression of receptors on the surface of breast cancer cells, and usually this method may provide a suitable therapeutic efficacy. However, the triple-negative breast cancer cells, which do not express any receptors, making the common treatment methods for breast cancer ineffective. According to research findings, these cells not only have BRCA1/2 gene mutations but also express a large amount of poly (ADP-ribose) polymerase (PARP), which plays a major role on the repairment of the single-stranded DNA damage in cells. As such reason, couples of PARP inhibitors have been approved by FDA for breast cancer treatment. However, based on some published literature reports, there is a great difference in the therapeutic effect of PARP inhibitors, mainly because the expression of PARP is different individually. To provide a quick and efficient monitoring method for the PARP expression in different patients, several radiolabeled PARP inhibitors, for instance, I-123-KX-1. Because of the high specificity and affinity of KX-1 for PARP in tumor cells, in the study present herein, the KX-1 will be labeled with iodine-131, which this isotope is the most common used for treatment in the department of nuclear medicine. Its radiochemical property (such as radiochemical purity and yield) and its affinity for PARP will be evaluated first, then this radiotracer will be applied to the animal models with different breast cancer cells inoculation to confirm its effectiveness for triple-negative breast cancer cells.

Project IDs

Project ID:PG11204-0202
External Project ID:112A001
StatusFinished
Effective start/end date01/01/2331/12/23

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