A Comparative Study of p53 Protein Overexpression and Human Papillomavirus in Bowen's Disease of Patients from Black Foot Disease Area with Chronic Arsenic Exposure and Patients of Nonendemic Area

  • Kuo, Tseng-Tong (PI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

烏腳病流行地區的住民在長期飲用含高量 砷之井水後,有較高各種癌症的盛行率.皮膚癌 是其中常見癌症之一.比較研究有無飲用含砷 井水之病人的皮膚癌將可提供瞭解砷在引起皮 膚癌的角色.因此本計劃擬比較研究烏腳病地 區飲用含砷井水病人之波文氏疾病與非烏腳病 地區無飲用含砷井水病人之波文氏疾病.因為 p53基因及人類乳頭狀病毒已有報告與波文氏疾 病有關,故本計劃擬以免疫組織化學法探討p53 蛋白之過度表現及以原位雜交法偵查有無人類 乳頭狀病毒之存在與否來比較兩組波文氏疾病 .研究p53蛋白,人類乳頭狀病毒,和砷之相互關係 將可供吾人對砷致癌機轉之瞭解.同時亦可供 進一步探討波文氏疾病致癌之分子生物學研究 之基礎.

Project IDs

Project ID:PB8412-1046
External Project ID:NSC85-2331-B182-039
StatusFinished
Effective start/end date01/08/9530/11/96

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