A Previous Study Was Established to Detect Sarcosine and Target Antigens Engrailed 2 and Anxan3 in Urine to Evaluate Prostate Cancer

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

本研究欲在尿液中偵測肌氨酸、Engrailed 2 與 ANXAN3 抗原等三種在前列腺癌患者尿液中有表達之分子，廷估由尿液偵測前列腺癌的可行性。實驗使用之尿液是在市售人工尿液中加入肌氨酸、EN2 抗原與 ANXAN3 抗原的實驗尿液，分別以電化學法與電化學/化學發光法建立感測平台，若初步評估可行，明年將提人體試驗計畫做進一步的驗證研究。本計畫將合成氫型葉綠酸以修飾金電極，其因(1)羧基與亞胺基團及(2)有機金屬的共軛結構，除可快速偵測肌氨酸外，金屬離子可與抗體分子形成配位的自組裝鍵結，快速製備成具專一性的生物探針，為偵測尿液中之EN2與ANXAN3，以評估/驗證在尿液中偵測前列腺癌的可行性。

Project IDs

Project ID:PB11207-4415
External Project ID:NSTC112-2221-E182-005
StatusFinished
Effective start/end date01/08/23 → 31/07/24

Keywords

  • Urine detection
  • Prostate cancer
  • Scronsine
  • Engrailed 2
  • ANXAN3

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