A Sub-Pg/Ml Blood Based Atn Biomarker Sensing Array by the Ultrahigh Q-Factor Metasurface with All Dielectric-Based Nano Structure for Alzheimer'S Diseases Detection

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

全介電質超穎表面非常適用於小分子量生物分子的低濃度偵測，因此亦可以應用於分析兩個小分子量的生物分子的專一性結合，例如DNA雜交反應，且不需要進行PCR的反應過程即可進行檢測，檢測過程可以有效簡化且快速。此外，本研究計劃是透過感測方式對阿茲海默症的生物標誌物，不需使用昂貴的核磁共振造影儀器，亦能夠有效降低醫療成本的開支。此外，本研究計劃提出新式的差分共振光譜術可以提高生物分子探用光譜偵測方式時，偵測極限不再受限於光譜儀的解析極限。

Project IDs

Project ID:PB11007-4379
External Project ID:MOST110-2221-E182-042
StatusFinished
Effective start/end date01/08/21 → 31/07/22

Keywords

  • metasurface
  • dielectric material
  • refractive index
  • β-amyloid protein
  • plasma p-tau217 protein
  • neurofilament light chain(NfL)
  • Alzheimer's disease andblood based biomarker

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