Alleviation of Wen-Dan Tang in Hyperglycemia and Hyperlipidemia in Diabetic and High Fat Dietary Induced Obese Rodent Models

Fat accumulation makes obesity to a complex endocrine and metabolic disorder that is related to insulin resistance, hyperglycemia and hyperlipidemia. Mounting evidence suggested that hepatoprotection and repress lipids profile of Wen-Dan Tang and imply Wen-Dan Tang may improve dyslipidemia and hyperglycemia, thus the approach to investigate the possible role of Wen-Dan Tang on the management of the metabolic diseases is increasingly based on understanding the underlying pathophysiology. Therefore, the aims of the current three-year research proposal are firstly to investigate whether the improved effects of Wen-Dan Tang on hyperglycemia and hyperlipidemia. If yes, secondly to define the mechanisms of Wen-Dan Tang reduced metabolic abnormalities on glucose and lipid. Specifically, we will apply both db/db diabetic mice and high-fat diet feeding obese mice models to study the alterations of metabolic disorders parameters as well as levels of lipid and glucose in liver/blood after Wen-Dan Tang treatment; In vitro model, 3T3-L1 adipocyte, and AML-12 hepatocyte are used as analyze the cellular mechanisms of glucose/lipid metabolism-related factors underlying metabolic disorder in response to Wen-Dan Tang treatment. Expectantly, we will reveal insights on mechanism of accompany dysfunction of glucose/lipid and highlight the more benefits of using Wen-Dan Tang in metabolic diseases.

Project ID:PC10301-0308
External Project ID:NSC102-2320-B182-015-MY3