Antioxidative magnetic nanoparticles based on natural antioxidants: Nanoparticle-cell interactions

Magnetic nanoparticles are needed as drug carriers in target therapeutics to reduce systemic toxicity of the treatment; particles with antioxidant activity will augment the treatment effect of the drug in diseases associated with elevated oxidative stress, including cancer, inflammatory and cardiovascular diseases. We aim to design magnetic nanoparticles with surface modified by natural catechins, which have been recently demonstrated to enhance internalization of particles by tumor cells. Catechin analogues will be attached via chelation of aromatic vicinal diols with Fe(III) at the iron oxide surface, or in a complex with albumin shell on the particles. Interaction of such particles with tumor and vascular cells and the subsequent cellular events will be characterized to evaluate the potential advantages of these particles in target therapy. Combination of the expertise from both teams is required to achieve such goals. Specific Aims are as following: Aim 1- Design/synthesis of antioxidative magnetic nanoparticles with bound natural antioxidants, such as catechins. Aim 2- Nanoparticle modification and optimization to ensure biocompatibility and efficient internalization by the target cells Aim 3- Evaluation of nanoparticle-cell interaction in vitro and in vivo

Project ID:PC10501-2514
External Project ID:MOST105-2923-B182-001-MY3