Application of Dan-Chi-Liu-Wei combination in SLE patients to taper steroid and to prevent disease flare

  • Chen, Chung-Jen (PI)

Project: Ministry of Health and WelfareMinistry of Health and Welfare Commission Research

Project Details


Systemic lupus erythematosus (SLE) is a severe chronic systemic autoimmune disease predominantly involving child-baering woman (15-45 years old). Though the ten years survival rate in SLE patients has been improved up to 80%-90%, there is rare cure. Most patients of SLE need long-term treatment of steroids and may suffer from disease flare about once every other year. Therefore, to taperthe dosage of steroid and to prevent disease flare is a critical issue to date. To date, antimalarial drugs and immunosuppressive agents have been used to resolve the above problems, but with limited effect and a lot of toxicity and complications. Therefore, we try to find a good way from traditional Chinese medicine (TCM) to help patients to get long-term health (including less steroid and less disease flare). Our research team including Immunologists, TCM expert and Pharmacy specialist to design the Dan-Chi-Liu-Wei combination, which is expected to be beneficial to taper steroid and to decrease the disease flare of SLE. This study is a randominzed-double blinded controlled trial. In total 160 SLE patients with mild to moderate activity (SLEDAI 2-12) will be recruited. They will be divided into experimental group taking Dan-Chi-Liu-Wei combination and control group. After six months of treatment, the decrease of steroid and rate of disease flare will be compaired between these two groups. We expect this study may provide a new way to help SLE patients to taper steroid and to decrease disease flare

Project IDs

Project ID:PG9606-0170
External Project ID:CCMP95-TP-025-1
Effective start/end date01/01/0731/12/07


  • SLE
  • steroid
  • flare
  • Dan-Chi-Liu-Wei combination


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