Application of Preconditioned-Mesenchymal Stem Cells and Its Derivatives Combined with Hyperbaric Oxygen Therapy for Treatment of Covid-19 Related Pulmonary Fibrosis Animal Model

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

SARS-CoV-2感染肺細胞後與好特發性肺纖維化(IPF)有相似的分子機制，先前我們移植低氧預處理之幹細胞有效改善Bleomycin所誘導之小鼠肺纖維化，本計畫藉此開發低氧預處理幹細胞及其衍生物結合已在臨床使用的高壓氧艙療法，評估合併治療之策略能否更有效的改善小鼠肺纖維化，期待未來可推廣對治療SARS-CoV-2感染引發肺纖維化的臨床試驗。

Project IDs

Project ID:PC11107-5105
External Project ID:MOST111-2314-B182-057
StatusFinished
Effective start/end date01/08/22 → 31/07/23

Keywords

  • SARS-CoV-2-infection induced pulmonary fibrosis
  • TGF-β1
  • inflammasome
  • Hyperbaric oxygen (HBO) therapy
  • preconditioned Mesenchymal Stem Cell and its derivatives

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