Project Details
Abstract
Proton therapy has gained more interest in recent years as it can deliver most of the
radiation dose to tumour whilst sparing the normal tissue. This is clearly demonstrated by the
increasing number of patients treated using such a state-of-the-art modality. Until September 9,
2014, there are fifty-one particle facilities in operation, twenty-seven facilities are under
construction, and more than 100,000 patients have been treated worldwide (PTCOG, 2014).
In Taiwan, there are five proton/carbon centres currently in the phase of initialisation and
Chang Gung Memorial Hospital, Linkou, will officially accept patients by middle 2015. In
addition to its excellent physical dose distribution, the radiation quality of proton beam is also
higher especially when the tumour is nearby critical organs, when low energy protons or
secondary particles (with higher LET) travel through low density organs, and while treating
small tumour where the RBE in distal edge may be sensitive to location. In this three-year
proposal, we will use microdosimetry method and implement a mini TEPC and
GEANT4/FLUKA/MCNPX codes to study the variation of lineal energy and to derive the 3D
biological weighted dose for the wobbling and pencil beam scanning system in CGMH proton
facility. The study of microdosimetry, RBE, 3D biological weighting dose distribution is,
therefore, critical for a better estimation of proton/carbon treatment doses. In addition, the
RBE variation may affect the dose accuracy of treatment planning. There are totally 15
proton/carbon treatment rooms which are proposed/planned/almost ready currently. Our
experiences can also benefit those proton facilities. In addition, there will be a huge
shortage of human resource on proton therapy and related researches. Partial of such
shortage can be filled with worker and researcher trained in this project.
Project IDs
Project ID:PC10408-2444
External Project ID:MOST104-2314-B182-043
External Project ID:MOST104-2314-B182-043
Status | Finished |
---|---|
Effective start/end date | 01/08/15 → 31/07/16 |
Keywords
- Microdosimetry
- Proton Therapy
- RBE
- TEPC
- Monte Carlo
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