Project Details
Abstract
Recently, much effort has been directed to the development of intelligent materials that respond to internal or external stimuli, in particular, pH, temperature. Stimuli-sensitive materials have emerged as novel programmable delivery systems in which the release of the encapsulated contents can be readily modulated by the stimulus. The aim of this project synthesis the novel biodegradable thermo- and pH-responsive materials. In the first year, we will synthesis two series of PNIPAAm-b-PMCC and PNIPAAm-b-PHpr pH/temperature-responsive block copolymers with PNIPAAm as the temperature-responsive segment, and PMCC or PHpr as the pH-responsive segment. In the second year, we will develop novel full biodegradable PNRHpr-b-PMCC pH/temperature-responsive block copolymers. The molecular weights are characterized with gel permeation chromatography and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The structure of polymers is determined by 1H NMR and FTIR. The lower critical solution temperature (LCST) will measure by UV with temperature control.
Project IDs
Project ID:PB9907-1714
External Project ID:NSC99-2221-E182-002
External Project ID:NSC99-2221-E182-002
Status | Finished |
---|---|
Effective start/end date | 01/08/10 → 31/07/11 |
Keywords
- Stimuli-sensitive material
- Amphiphilic copolymers
- micelle
- Drug controlled released
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