Cardioprotective Roles of Il6 and Ccl5-Programed Mdscs on Cardiac Maladaptive Remodeling in Hfd-Induced Obese Insulin Resistant Mice

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

本計畫預期結果將會對發炎激素與趨化因子(IL6,CCL5以及 IL6/CCL5)在MDSC之編程,以及其對高脂飲食造成肥胖胰島素阻抗之心臟適應不良性重塑之影響提供全面的訊息。除此之外本計畫將對MDSC之臨床遠景提供機制性的論述來與糖尿病心肌病變與心衰竭做連結探討,並且也可以拓展基礎與臨床上之轉譯醫學研究,促進基礎研究在臨床上之應用性。

Project IDs

Project ID:PC11207-2128
External Project ID:NSTC112-2320-B182-006-MY3
StatusActive
Effective start/end date01/08/2331/07/24

Keywords

  • Obesity
  • diabetes
  • cardiac maladaptive remodeling
  • MDSC
  • IL6 and CCL5

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