Characterization of Ganoderma Lucidum Enhanced Bacterium on Amelioration of Obesity

  • Lai, Hsin-Chih (PI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


Gut microbiome is essential for maintaining the homeostasis of local and systemic immunity in the host. Dysbiosis of gut microbiome is reported to be closely linked to long term chronic inflammation and diseases, including obesity, metabolic syndrome, diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and cancer. Our previous study, Ganoderma lucidum (GL) reduces obesity in mice by modulating the composition of the gut microbiota, indicated the composition of gut microbiota is changed by polysaccharides of G. lucidum, leading to reduced body weight in high fat diet (HFD) mice. However, which members in the gut microbiome are involved in such ameliorative effect remains not known. Based on our study results, a bacterium temporarily named CGB-1 belonging to Bacteroidetes phyla, is enriched by GL treatment in chow and HFD mice. Preliminary results on CGB-1 indicated CGB-1 significantly reduces body weight, epidydimal fat, subcutaneous fat, and epididymal adipocyte size in a dose-dependent manner. In this proposal, we aim to elucidate the effect and mechanism CGB-1 in amelioration of obesity. The research proposal are subdivided into three stages: (1) Whether GL enhanced CGB-1 can prevent HFD-induced obesity and related syndromes such as non-alcoholic fatty liver (NAFLD), NASH, insulin resistance and systematic inflammations in vivo; (2) To characterize composition of gut microbiome and metabolites after oral administration of CGB-1 in vivo; and (3) to unravel which active components derived from CGB-1 is involved in such effect. This research project will shed light on the underlying mechanism on how CGB-1 may prevent obesity in mice and further evaluate the potential applicability of CGB-1 as a probiotic for clinical application.

Project IDs

Project ID:PC10601-0851
External Project ID:MOST105-2320-B182-032-MY3
Effective start/end date01/08/1731/07/18


  • Obesity
  • inflammations
  • Gut microbiome
  • Probiotic
  • Bacteroidetes
  • Ganoderma lucidum (WEGL)


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