Characterization of Tumor Immune Microenvironment by Microsatellite Instability Status in Gastric Cancer

  • Huang, Wen-Kuan (PI)
  • Kung, Hsing Jien (CoPI)
  • Yeh, Ta-Sen (CoPI)
  • Yeh, Chun Nan (CoPI)

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

本研究透過生物資訊分析與臨床樣本驗證進一步了解MSI胃癌免疫微環境的分子特徵,我們初步結果顯示TIGIT-nectin family在MSI胃癌腫瘤高度表達,本研究將利用活體實驗去探索targeting TIGIT是否能提升MSI胃癌對於免疫治療的反應。另外,MSI胃癌腫瘤呈現較高的glycolysis,我們也將探索是否抑制glycolysis能改善MSI腫瘤對於免疫反應的抗性。

Project IDs

Project ID:PC11107-6974
External Project ID:MOST111-2314-B182-066
StatusFinished
Effective start/end date01/08/22 → 31/07/23

Keywords

  • microsatellite instability
  • tumor immune microenvironment
  • gastric cancer
  • single cell analysis

Access Project

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
View full fingerprint