Compared the Differences between Health Individuals and Allergic Rhinitis Pations and Evaluated the Effect of Treatment by Chinese Herbal Formula

Perennial allergic rhinitis is an important disease in traditional Chinese medicine (TCM) due to its high prevalence rate in Taiwan. In our previous studies, a new mixed formula of Chinese herbs was evaluated for the treatment of allergic rhinitis. In these studies, we found that immunoduoatory effects of Chinese medicine include: CD4+ T lymphocytes; Regulatory T cells; Dendritic cells, and Regulatory B cells. These results allow us to confirm the immunomodulatory effects of mixed formula of traditional Chinese medicine.In recent years, more and more attention has been paid to the effects of gut microbiota on immune-modulation. Many immunomodulaotry effects of allergic diseases are considered to be closely related to gut bacteria. However, the research on allergic rhinitis is still rare, especially related to TCM treatment. From our previous studies, it has been confirmed that TCM have an immunomodulatory effect on allergic rhinitis. Whether or not they are associated with gut microbiota changes is still unknown. This study will compare the distribution of gut microbiota in normal and allergic rhinitis patients. In addition, we will compare the changes of gut microbiota in allergic patients before and after TCM treatment for understand whether the TCM treatment of allergic rhinitis is through a immunomodulatory effects that is based on changes in gut microbiota. The study results is very important and helpful for the understanding of the immune mechanism of allergic rhinitis and TCM treatment, also helpful for the clinical physicians.

Project ID:PC10707-0101
External Project ID:MOST107-2320-B182-015