Convection Enhanced Delivery with Pd-L1 Targeted Icg/Resiquimod-Loaded Liposomes Triggered by Laser Interstitial Thermal Therapy for Enhanced Glioma in Situ Vaccination.

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

惡性膠質瘤的治療停滯不前，腫瘤復發病人存活率極低，不僅傷害病人，更造成其家庭與社會極大損失。雷射消融技術能提升腫瘤免疫反應，為復發膠質瘤治療帶來新希望。本計畫結合奈米微脂體技術、併增強對流傳輸、雷射間質性熱治療，建立腦瘤免疫疫苗治療方式。2014年癌症免疫療法市場為17億美元，2020年已達到308億美元，將會是癌症治療產品中的明日之星。本計畫利用創新醫材，輔以奈米顆粒，提升樹突細胞的抗原呈現，增加T細胞免疫治療力，逆轉腦癌的低免疫反應。此外，以奈米顆粒劑型取代溶瘤病毒式免疫疫苗，將成為癌症免疫疫苗技術的特色，研究成果將發表於高分學術期刊，並申請生醫新藥專利。

Project IDs

Project ID:PC11107-4801
External Project ID:MOST111-2314-B182-054-MY3
StatusFinished
Effective start/end date01/08/22 → 31/07/23

Keywords

  • glioma
  • blood-brain barrier
  • in situ vaccination
  • convection enhanced delivery
  • laser interstitial thermotherapy
  • T cell infiltration

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