Convulsive Seizures and Tremor: the Generation of Oscillatory Motor Cortical Discharges and Enlightenment on the Rationales of Intervention

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

哺乳動物的認知和隨意運動之發生與控制過程，常仰賴腦皮質網路的節律性神經放電及運算，然而其中關鍵的分子或細胞機制仍然相當不清楚。我們將從兩種常見的神經疾病表現，即癲癇抽搐和振顫的深入研究中獲得創新見解。透過本計畫的執行，期望能夠解開運動皮質節律發生的前所未明的新機制。並了解在不同之生理或病態生理情況下，皮質之內建震盪機制，所可能受到的外部迴路的不同調控。也期待透過此一計畫之執行所增進之上述理解，能夠更進一步促成對於相關重大神經疾病之創新治療。

Project IDs

Project ID:PA11307-1298
External Project ID:NSTC113-2311-B182-004-MY3
StatusActive
Effective start/end date01/08/24 → 31/07/25

Keywords

  • anticonvulsants
  • basal ganglia
  • brain rhythms
  • cortico-subcortical re-entrant loops
  • gap junction
  • electrical synapse
  • electrophysiology
  • epilepsy
  • glutamate
  • intrinsic rhythms
  • paroxysmal depolarizing shift
  • motor cortex
  • oscillating discharges
  • tremor

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