Deciphering the Role of G3bp1 and Associated Signaling Pathways in Corneal Epithelial Cells in Response to Negative Pressure

Sun, Chi-Chin (PI)

School of Medicine

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

本研究若能順利執行並揭示G3BP1在角膜傷口癒合中的角色與負壓治療的分子機制，將能：幫助因糖尿病、化學損傷及慢性角膜病變導致視力受損的患者，改善其生活品質並減少失明風險。提供針對持續性角膜上皮缺損（PCED）的新治療策略，降低復明手術的需求，進一步減少醫療資源的消耗與社會經濟負擔。證實負壓治療對G3BP1的調控作用，探索其在細胞應激反應、增殖與遷移中的分子機制，並發展基於G3BP1的創新治療方法，為角膜再生醫學與其他組織修復領域的應用帶來突破性進展。

Project IDs

Project ID:PC11407-5260
External Project ID:NSTC114-2314-B182-026

Status	Active
Effective start/end date	01/08/25 → 31/07/26

Keywords

Corneal epithelial wound healing
G3BP1
Negative pressure wound therapy (NPWT)
migration
stress response
persistent corneal epithelial defect (PCED)

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https://www.grb.gov.tw/search/planDetail?id=18000793

Deciphering the Role of G3bp1 and Associated Signaling Pathways in Corneal Epithelial Cells in Response to Negative Pressure

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Abstract

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