Development and Application of Magnetic and Photosensitive Nanodrug for the Photo- and Chemo-Therapy of Tumors

The occurrence and death rates caused by malignant cancers are gradually increased recently. Most patients are treated using surgical resections. However, the residual cancer cells always immersion and infection to the important tissues, which can’t be removed by surgical resections. Therefore, the post-treatments by radiotherapy and chemotherapy are necessary to avoid the recurrence and/or metastatic cancers. It is confirmed that the chemotherapy is always a necessary procedure for malignant cancer treatment. However, the efficiency of commercialized chemotherapeutic agents for the treatment of malignant cancers is limited by side effects such as the fester of mucous membrane, palpitation, anemia, insomnia, dizzy, vomit, or others, which largely infects the live quality of patients. In this study, we are developing the multifunctional drug-carrier system for the magnetic nanodrugs, which has the combined efficiencies of chemical therapy and photothermal or photodynamic therapy. The animal models for the chemotherapy efficiencies of malignant glioma, prostate cancer, and bladder cancer are explored. The main purpose of this study is to develop the multifuctional and magnetic nanodrug carrier system with high chemotherapy efficiency, which can largely reduce the used drug dosages and increase the survive time and live quality of patients. This is a three-year project, the major subjects of this project are shown as follows: 1. Synthesis of water dispensible and stable magnetic nano-graphene (NG) and characterize its structual and physical properties 2. Synthesis of water dispensible and stable nano-rod gold (NRG) with various aspect ratios (length/diameter) and bound the NRG on the surface of NG (NRG-NG) and characterize its structual and physical properties and photothermal efficiency 3. Bioconjugations of various drugs for the specific cancer chemotherapies on the surface of magnetic NRG-NG (Drug-NRG-NG) 4. Analyses of the drug payload and activity of magnetic Drug-NRG-NG 5. Cytotoxic effects of magnetic Drug-NRG-NG 6. In-vitro magnetic guiding and photothermal efficiency of magnetic Drug-NRG-NG 7. Cancer cell uptake studies of magnetic Drug-NRG-NG 8. In-vivo bladder cancer test of magnetic Drug-NRG-NG 9. In-vivo prostate cancer test of magnetic Drug-NRG-NG 10. In-vivo malignant glioma test of magnetic Drug-NRG-NG

Project ID:PB10107-1726
External Project ID:NSC101-2221-E182-011-MY3