Project Details
Abstract
Impaired vision can directly affect the quality of our lives. Although medical technology continues to advance, it shows that the number of blind people has increased at a rate that doubles every two or three decades. Therefore, eye diseases cause large-scale economic impacts. Immediate fundus photography is an important method for studying retinal diseases, which can be used to present specific diseased tissues, or the results of post-treatment changes, such as choroidal changes, retinopathy, retinal-vitricular interface lesions, or vitreous lesions. In order to develop translational medical verification for new treatments, the purpose of this project is to develop a low-cost, high-resolution, small animal fundus photography system. In the past nine months, three major shortcomings of the "small experimental animal fundus imaging system" of our preliminary version, including the light source, resolution and perspective, have been improved.At present, we have achieved several goals, including 1. We have utilized the LED cold light source for optical coaxial design and greatly extended the mouse cataract by repeatedly testing and correcting the wavelength and brightness of the light source. 2. In the improvement of the resolution of the bright field image, in addition to changing the wavelength of the light source and increasing the brightness, we have also corrected the distance between the combination of the lenticular lens and the optical path, and the resolution has been significantly improved. 3. When strengthening the resolution of bright field of view, we found that the combination of the modified optical lens and the direction of the optical path can change the viewing angle of the ophthalmoscope; 4. The eye-catching design, after re-adjusting the optical lens combination and the optical path, finally corrected to a non-contact observation design similar to the clinical ophthalmoscope, and has become the leading design of the known small animal fundus photography system.In the next year's plan, in addition to completing the patent application for the two or three latest designs mentioned above, we will also improve the image capture of this small animal fundus photography device by implanting the newly acquired high-speed image capture device. In addition, we will also try to increase the design of the variable viewing angle, initially aiming at 2-3 perspectives (increasing 1-2 different viewing angles), and secondly, completing at least 2-3 different wavelengths of fluorescent images. Capture photography, including single photography and dynamic photography records. Finally, in addition to the patent applications mentioned above, we will also prepare a plan for technology transfer and mass production of equipment. Finally, the successful completion of the design and mass production of this equipment is expected to solve the problem of the lack of this system to expand the field of eye research, and at the same time promote the translation of clinical research in the field of ophthalmology research.
Project IDs
Project ID:PC10811-0018
External Project ID:MOST108-2622-B182-005-CC2
External Project ID:MOST108-2622-B182-005-CC2
Status | Finished |
---|---|
Effective start/end date | 01/11/19 → 31/10/20 |
Keywords
- Retinopathies
- fundus imaging
- retinal images
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