Development of an On-Line Positron Imager for Treatment Response Monitoring in Charged-Particle Therapy( II - III )

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


Charged-particle therapy is one of the most precise modalities of external radiation therapy. Unlike a photon beam that has a high entrance dose and decreases progressively while passing through the body, a proton/heavy-ion beam can penetrate through tissues and deposit most of its energy near the end of its track, known as the Bragg peak. However, proton/heavy-ion therapy is also more sensitive to uncertainties in treatment planning and delivery compared to photon therapy. Range inaccuracy is particularly of concern. If the range of the beam is known more precisely, range margins can be reduced, and new treatment plan designs would become feasible, leading to a lower dose to the patient. Continuous monitoring of deviations in the range can also facilitate adaptations over the course of treatment. In this proposal, we propose to develop an on-line positron imager for particle therapy. The imager is expected to have two functions: one is to perform dynamic imaging of positron emitters for quantifying the biological washout rate of the tumors, which is prospectively associated with the changes in tumor biology With treatment. The other is to perform charged-particle range verification through integration with a prompt gamma imager to be an on-line two-in-one imager for adaptive particle therapy in the future.

Project IDs

Project ID:PB10907-4721
External Project ID:MOST109-2221-E182-004-MY2
Effective start/end date01/08/2031/07/21


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