Development of Anisomeles indica to mitigate gastric ulcer

Gastric ulcer is a very common global disease nowadays. The etiology of gastric ulcer included an imbalance between offensive factors (i.e. gastric acid and Helicobacter pylori) and defensive factors (i.e. mucin and prostaglandin). Several naturally derived products, including extracts of medicinal plants and isolated bioactive molecules, harbor gastroprotective activity. Anisomeles indica is a traditional Chinese herb called "yu-chen-tsao" in Chinese. Recent studies have been demonstrated that A. indica possesses anti-inflammatory activity and has been used to treat gastrointestinal diseases. Most importantly, ovatodiolide, a pure constituent isolated from A. indica, has been demonstrated to possess bactericidal activity against H. pylori in our recent study. However, the constituents involved in A. indica that contributed to gastroprotective properties remained to be illustrated. Therefore, this industry-academic collaboration study aims to investigate the effects of A. indica constituents on anti-ulcer and anti-inflammatory activities by using cell-based and animal models. The results from this study will provide a rational base for A. indica in the treatment of gastric ulcer and will develop the plant constituents as gastroprotective agents in the near future.

Project ID:PC10911-0010
External Project ID:MOST109-2622-B182-002