Development of Functional Optical Coherence Tomography(II)

Optical coherence tomography (OCT) has the advantages of non-invasive, depth-resolved and high-speed imaging without the destruction of samples. OCT can reconstruct the two-dimensional or three-dimensional microstructures with the resolution in micrometer scale, enabling the measurable imaging depth to achieve 3 mm below the sample surface. In first year of this proposal, we have developed a high-speed swept source, and we still continue to improve the bandwidth of laser output spectrum. In the second year, we propose a novel OCT configuration, two-reference-arm interferometer, with the swept source developed in the first year. With the two-reference configuration, the phase noise from dispersion and polarization fluctuation due to fiber can be eliminated, effectively increase the measurable range of blood velocity. In the third year, the swept source is also implemented for the development of polarization-sensitive OCT system. Every adjacent A-scans will be set to be the horizontal and vertical polarization states, respectively. Then, the polarization information from the sample can be detected by the balanced detectors, sequentially. Such structure can eliminate the phase noise due to the changes in polarization states without scarifying the imaging speed of OCT system. Also, the study on observation and measurement of drug delivery will be performed.

Project ID:PB10501-3726
External Project ID:MOST104-2221-E182-027-MY2