Development of Human Papillomavirus Transmission Dynamic Model and Its Related Cost Effectiveness in Vaccination Prevention

Due to persistent infection with high-risk human papillomavirus, there are about 1,700 people suffer from invasive cervical cancer per year in Taiwan. Pap smear screening policy has been implemented since 1974, and cervical cancer screening registry system was also developed by Health Promotion Administration, Ministry of Health and Welfare in 1994. Prophylactic human papillomavirus vaccine has been administered in Taiwan since 2008 and vaccination subsidies are gradually expanded to subjects who received vaccination by government. The purposes of these strategies are to protect human from human papillomavirus infection and the occurrence of disease related to human papillomavirus. Early discovery and preventive treatment of disease can reduce the loss of national resources and save human life. However, the cost of screening, vaccines, and related medical are enormous. Thus, the objective of this study is to develop a transmission dynamic model that mimics the natural history of HPV infection and disease in Taiwan to provide important and valuable simulated information. In this study, a transmission dynamic model will be established to simulate the natural history of HPV infection and disease and to evaluate the cost-effectiveness of epidemiologic and economic consequences of alternative vaccination strategies. We will apply National Health Insurance Research Database (NHIRD) from Health and Welfare Data Science Center, Ministry of Health and Welfare (HWDC, MOHW) and its related to incorporate into this project. All databases will be managed and analyzed to obtain estimations of parameter in model-building. Some parameters will be derived using systematic review and meta-analysis from journals. This study expects to obtain more precise long-term results of the vaccination, and will provide more valuable information to the government such as MOHWto optimize the use of limited medical resources.

Project ID:PF10507-1705
External Project ID:MOST105-2410-H182-018