Development of Multiple Biomarkers for Early Detection, Prognosis and Therapy Assessment of Colorectal Cancer

  • Chan, Err-Cheng (PI)
  • Chen, Jinn Shiun (CoPI)
  • Fan, Chung Wei (CoPI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

Colorectal cancer (CRC) is a malignant cancer, and it is the third leading cause of cancer mortality in Taiwan. The tumor stage at the first time of diagnosis is the most important prognosis factor of patients with CRC. So far, there are no suitable biomarkers could be clinically used for CRC early detection, prognosis prediction and therapy outcome evaluation. We adopted a prospective-specimen-collection, retrospective-blinded-evaluation design for this translational research project. The executing strategies of this study are as follow: First of all, we select 10~15 candidate markers from the differential expression proteins discovered from our previous proteomic studies for following analysis. By integrating the clinical resources of The Chang Gung Memory Hospital, we plan to evaluate the clinical usefulness of the each candidate marker in statistic significant numbers of clinical samples. Finally, we try to combine several markers into a multiple biomarker panel to improve the diagnostic sensitivity, and to investigate the potential to discriminate CRC from the other type of cancers by different reactive profiles.

Project IDs

Project ID:PC10008-0917
External Project ID:NSC100-2321-B182-006
StatusFinished
Effective start/end date01/08/1131/07/12

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