Project Details
Abstract
Optical Coherence Microscopy (OCM) is a non-invasive real-time cell-level imaging
technique based on optical coherence tomography (OCT) and confocal microscopy. OCM can
provide real-time image with resolution of about 1~2 microns, which is comparable to general
optical microscopy with resolution of about 0.2~2 microns. In clinical applications, biopsy is
the diagnostic golden rule for cancer and precancerous conditions. Pathologists examine the
histological architecture of the removed tissue’s cells from the suspected diseased region
under an optical microscope. However the tissue preparative procedure including fixing,
slicing, and staining consumes much time so that the real-time diagnosis is impossible.
Generally OCT has the resolution of about 7~15 microns, which is not enough for cell
imaging. OCM improves the resolution to 1~2 microns, hence the optical biopsy becomes
possible. In this project, we will build up an OCM system and use the GPU technique to
increase the image process speed for real-time imaging in the first year. And then an optical
microscope system will be integrated with the OCM system for co-registered imaging in the
second year to evaluate the consistency of the two imaging modalities. In the third year, we
will develop a scanning head for clinical application
Project IDs
Project ID:PB10107-0944
External Project ID:NSC101-2218-E182-006
External Project ID:NSC101-2218-E182-006
Status | Finished |
---|---|
Effective start/end date | 01/08/12 → 31/07/13 |
Keywords
- Optical Coherence Microscopy
- optical biopsy
- diagnosis for cancer and precancerous conditions
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