Project Details
Abstract
Biopsy is the standard clinical cancer diagnosis method. Cancer-suspected tissue is removed by
operation procedure and then the specimen is made through a series of processes including slicing, fixing,
staining, impregnating, and so on. By microscopy, the pathologists observe the cell structure, cell distribution,
or nucleus size of the specimen to judge the cancerous stage of the suspected tissue. However, biopsy has
some unavoidable disadvantages. For example, tissue-removing causes the patients painful, error-sampling
position would cause false-negative diagnosis, and the time-consuming specimen preparation processes make
real-time diagnosis impossible.
Optical Coherence Tomography, (OCT) is a real-time non-invasive imaging technique with resolution
about 5~15 microns. It has been widely used in ophthalmology for retina or cornea structure imaging. The
resolution of OCT is sufficient for imaging the tissue structure with scale about several tens to hundreds
microns. However, OCT is hard to observe the cell structure or nucleus size with scale about 3~10 microns.
This project will develop Optical Coherence Microscopy, (OCM) which retains the OCT advantages of
high-speed and non-invasive characteristics and even improves the resolution up to 1~3 microns approaching
the resolution of general microscope. Without the need of removing tissue from patients and the need of
specimen preparation processes, OCM can obtain the biopsy images in vivo. Hence OCM can potentially
realize "Optical Biopsy."
In the on-going project started last year, we built up a basic OCM system. In the first year of this project,
to achieve real-time imaging, we will accelerate image processing speed by using graphic processing unit
(GPU). In the second year, we will integrate a microscope with our OCM system for co-registered imaging to
verify the consistency between biopsy and OCM images. In the third year, we will develop a scanning probe
for clinical trial.
Project IDs
Project ID:PB10207-1912
External Project ID:NSC102-2221-E182-047
External Project ID:NSC102-2221-E182-047
Status | Finished |
---|---|
Effective start/end date | 01/08/13 → 31/07/14 |
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.