Development of Ph Sensitive Hydrogel Based on Polymanitol and Its Application in Local Cancer Therapy

  • Yang, Jen-Ming (PI)
  • Chang, Yen Hsiang (CoPI)
  • Tsai, Hsieh Chih (CoPI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

The purpose of this study was to develop an acid-base sensitive polymer hydrogel and implanted into the tumor by in situ injection to achieve the long-term release of the drug. The aim of current research is dedicated to improving the effects of chemotherapy in the cancer tissue and minimize the side effect for normal tissue. The purpose of design an acid-base reaction hydrogel for implantation is due to the weak acid state of the surrounding environment of the tumor. After implanted the hydrogels, it will rapidly gel around the tumor to achieve the continues release effect of the drug. The rate of drug release ca be manipulated by changing the structure/combination of its gel state, drug loading, structural stability, and gelling pH, which were the main items discussed in the early stages of this study. Later, this project will discuss the drug load by adding polymannitol with different molecular structures and molecular weights. Finally, the release of drug from the pH sensitive hydrogel will also be discussed and evaluation it’s anticancer activity. We hope that the pH sensitive hydrogels developed in this study will open a new therapeutic way for cancer in situ chemotherapy therapy

Project IDs

Project ID:PC10907-1730
External Project ID:MOST109-2221-E182-054
StatusFinished
Effective start/end date01/08/2031/07/21

Keywords

  • hyperbranched polymer
  • pH response
  • injectable hydrogel
  • drug-release carriers

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