Development of Proton Radiography and Proton Ct for Range Verification

Compared with the photon therapy, proton therapy provides a third degree of freedom for patient dose delivery, in addition to field size in both directions. Bragg peak, however, also led to a greater risk on dose delivery owing to its gradient. So far, the safe margin for most proton therapy centre is 3.5% + 1-3 mm. Range verification can greatly reduce the damage to normal tissue. This project proposed to develop a unique technique for proton radiography and proton CT, named Discrete Range Modulation (DRM) benefited from CGMH wobbling and layer stacking SOBP techniques. DRM has many strengths: (1) is more accurate on measuring water equivalent thickness (WET); (2) is more precise with lower dose; (3) can solve mixed beam problem owing to multiple Coulomb scattering; (4) can solely acquire DRM images, and (5) can also provide CRM images by weighted sum of CRM images. This two-year project has five major tasks: (1) Monte Carlo simulation; (2) irradiation parameter design; (3) reducing image defect caused by multiple Coulomb scattering; (4) image quality assessment; and (5) 3D image reconstruction. In addition, there will be a huge shortage of human resource on proton therapy and related researches. Partial of such shortage can be filled with worker and researcher trained in this project.

Project ID:PC10701-0976
External Project ID:MOST106-2314-B182-016-MY2