Dissecting the Signaling Crosstalk between Cell Clusters and the Molecular Mechanisms Overriding the Reversible to Irreversible Tubulointerstitial Fibrosis

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

慢性腎臟疾病是一個全球性的健康問題,也是高齡化社會公共衛生支出的巨大負擔與隱憂。在台灣因腎臟衰竭須接受洗腎的人口居高不下,所耗費的醫療資源更佔健保支出之冠。此研究計畫,在更全面了解慢性腎臟疾病,尤其其中最重要導致腎衰竭的因素“腎臟纖維化”的過程與機制。我們已建立獨有,成熟且穩定的動物模式,搭配目前最先進,微觀無偏私的單細胞定序,加上已建立的機制基礎,相信我們具備充足的能力完成此計畫。計畫的研究成果,除了為學術醫療知識奠定更多基礎,更宏觀的視野,期待藥物的篩選更能夠為台灣社會經濟有長遠的建樹。

Project IDs

Project ID:PC11207-1391
External Project ID:NSTC112-2320-B182-005-MY3
StatusFinished
Effective start/end date01/08/2331/07/24

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