Dual Regulatory Mechanism of Itga6 on the Invasion and Radioresistance of Areca Nut Induced Head-Neck Cancer Cells

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

頭頸癌是台灣十大癌症之一,而因頭頸癌好發在中年男性,對家庭及社會無形中造成相當大的影響。惡性頭頸癌常因轉移或復發造成不可逆的後果,而細胞之高侵襲性與放射抗性即為此不可逆之主因。本研究中,本計畫擬將探討,ITGA6在檳榔誘發頭頸癌機制中,可能兼具調控細胞侵襲及放射抗性之關鍵分子機制。這些研究成果,可進一步做為日後應用於預測放療效益、預後或分子治療之學理基礎,預期對本土癌症醫學將有學術及社會之貢獻。

Project IDs

Project ID:PC11008-0570
External Project ID:MOST108-2320-B182-029-MY3
StatusFinished
Effective start/end date01/08/2131/07/22

Keywords

  • ITGA6
  • heqc-neck cancer
  • areca nut
  • cell invasion
  • radioresistance
  • molecular mechanism

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