EBV Reactivation and Non-Remission of Rheumatoid Arthritis

  • Chen, Chung-Jen (PI)
  • Cheng, Tien-Tsai (CoPI)
  • Huang, Chao-Cheng (CoPI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


Though lots of medication have been developed for treatment of rheumatoid athritis (RA), the remiison rate is not satisfactory. In 2008, Sokka et al. reported in an international survey that remission rate of RA was 8.6%~19.6% according to different criteria . It implys that at least 80% of patients do not get remission by current therapy. Recently, we carefully reviewed pathologic findings upon our patients receiving synovectomy due to refractory synovitis in knee joint. Lots of lymphocytes and plasma cell infiltrarion were abundant in their synovial tissue. As we know, plasma cells are responsible with autoantibody ( such as rheumatoid factor and anti-CCP) and derived from B cells. B cells were well known to carry CR2 molecule, the EBV receptor. It is also knwon that EBV can cause immortalization of B cell. These information suggests that EBV infection, esp. for reactivation may play an important role upon disease perpetuation to cause difficulty of remission in patients with RA. In this study, we hypothesize that EBV reactivation is related with non-remission in RA patients. Thirty synovial tissue from synovectomy due to refractory synovitis (non-remission) will be compared with thirty samples from OA. In situ hybridization of EBV DNA, In situ hybridization of RNA and Immunohistochemistry will be done. This study will provide an evidence to support EBV reactivation is strongly related with non-remission of RA. It will be important to resolve the puzzle of non-remission in RA in the future.

Project IDs

Project ID:PC9907-2537
External Project ID:NSC99-2314-B182-011
Effective start/end date01/08/1031/07/11


  • Rheumatoid arthritis (RA)
  • EBV reactivation
  • Epstein-Barr virus (EBV)-encoded small RNA1 (EBER1)
  • TLR3


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