Effect of Alternative Aerobic and Resistance Exercise Training on Inflammatory Thrombosis in Patients with Heart Failure

Heart failure (HF) is a major and increasingly common cardiovascular syndrome, and is the end result of many cardiovascular disorders. HF has been recognized to predispose to prothrombotic status, which is often the cause of death. Elevated coagulant factors, endothelial abnormalities, and increased pro-inflammatory cytokines have been reported as coagulation indices in patients with HF who majorly suffered from ischemic cardiomyopathy. Platelet and neutrophil co-localization to the wall of inflammatory vessels is an essential component of a multistep cascade in thrombosis and inflammation. Platelet activation in pathological vascular conditions, such as fissured atheromas or growing thrombi, may lead to neutrophil stimulation, which can amplify the thrombtic process by activating platelets. Inflammation-induced shedding of procoagulant-rich microparticles from neutrophils plays critical roles in arterial thrombosis, which is a major contributing factor for atherothrombotic occlusion of blood vessels. Physical training elicits beneficial effects on neurohumoral, inflammatory, redox, and thrombotic/coagulatory modification, leading to improvement in health-related functional capacity and quality of life. Which exercise prescription depresses inflammatory thrombosis in patients with heart failure has is controversial. Compared to continuous moderate exercise training, exercise training with alternative high and moderate intensities has better cardiovascular adaptation effect for healthy people or patients with cardiovascular diseases. However, studies of the relationship between alternative aerobic/resistance exercise training and inflammatory thrombosis mediated by neutrophil/platelet have not yet been investigated. This study would like to clarify how the alternative aerobic/resistance exercise training affects the inflammatory thrombosis and its mechanisms. Accordingly, we will conduct this three-year study that includes 1st year study: the effects of various exercise regimens on platelet activity and blood coagulation system under shear flow; and 2nd year: the effects of various exercise regimens on reciprocal modulation of platelet and neutrophil activities under shear flow; and 3rd year: the effects of various exercise regimens on neutrophil oxidative burst under adherence to surface-adherent platelets under shear flow. We expect that these results obtained from this study can aid in determining appropriate exercise intervention to improve aerobic fitness and simultaneously to modulate interaction between platelets and neutrophils and further minimize the risk of inflammatory thrombosis in patients with heart failure.

Project ID:PC10401-0214
External Project ID:NSC102-2628-B182-018-MY3