Establish a Dose Assessment System for the Accelerator Based Boron Neutron Capture Therapy

Chang Gung Memorial Hospital (CGMH), Linkou is expected to launch an accelerator based boron neutron capture therapy (AB-BNCT) in 2022, and will official accept patients from 2027. The AB-BNCT, which is a targeted therapy for patients especially with head and neck cancer as well as liver cancer in the hope of saving more lives. Japan initially proposed the use of AB-BNCT utilizing secondary neutrons from specific targets bombarded from accelerated protons. AB-BNCT offers the advantages of high fluence, low costs and safe to be used in a hospital. However, there is still much research vacancy for the 3D biological dosimetry in AB-BNCT. This project will establish a three-dimensional evaluation system for the relative biological effectiveness (RBE) dose, which combines the Monte Carlo simulation with the microdosimetry and particle therapy. The dynamic kinetic microdosimetry model and the local effect model will be utilized for the calculation of the RBE as well as the verification of the measurement. By comparing the differences in the biologically weighted doses between the BNCT from the THOR reactor and AB-BNCT from the University of Osaka, we can construct a dosimetric platform for the future AB-BNCT treatment in CGMH, Linkou.

Project ID:PC10907-0904
External Project ID:MOST109-2314-B182-020