Project Details
Abstract
The purpose of this three-year project intends to establish a molecular imaging-based
translational platform to demonstrate the effectiveness and feasibility of brain drug delivery
through tight junction with the technique of focused ultrasound induced blood-brain barrier
(BBB) opening, which in on going developed from our group. In this three-year project, we
aim to construct a universal platform which intends to provide novel treatment technology as
well as therapeutic means to be translational and brings the opportunity to be of clinically
impact. We (from the General project) will be used to support the focused ultrasound
brain-drug delivery technology for the assessment of BBB-disruption and brain drug delivery
by using small-animal brain-tumor model as our target. Other sub-projects will support to
develop specific novel molecular imaging technology including the focused ultrasound
induced BBB opening technology, , Quantitative molecular imaging technology as the second
tool (Sub-project #1), High-frequency ultrasonic imaging and liposome based microbubbles
as the third molecular imaging tools (Sub-project #2), and the Photoacoustic imaging
technology as well as the nanorods as the 4th molecular imaging tools (Sub-projects #3).
Technology needs to be established in this general application includes: (1) In order to
achieve the goal of establishing a molecular imaging-based translational platform for focused
ultrasound induced brain drug delivery, the following techniques from this application
(General project) will be developed; (2) To establish a rat glioma multiform (GBM) brain
tumor model; (3) To establish microarray and tissuomics assay rat GBM model for validation
at molecular and cellular level; (4) To establish an integrated pre-clinical multi-modalities
molecular imaging software for rat GBM to validate drug delivery system using focused
ultrasound technique to open BBB opening in rat brain; (5) To establish a system approach
informatics in rat GBM, before and after treatment using focused ultrasound to open the BBB
and compare with the result of traditional treatment mode.
Project IDs
Project ID:PC9812-0317
External Project ID:NSC98-2218-E182-008
External Project ID:NSC98-2218-E182-008
Status | Finished |
---|---|
Effective start/end date | 01/11/09 → 31/10/10 |
Keywords
- focused ultrasound
- drug delivery
- molecular images
- microarray
- tissuomics
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