Establish a Molecular Imaging-Based Translational Platform for Pre-Clinical Studies of Focused Ultrasound Enhanced Brain Drug Delivery (I)

  • Yen, Tzue-Chen (PI)
  • Hua, Mu-Yi (CoPI)
  • Li, Meng Lin (CoPI)
  • Liu, Hao-Li (CoPI)
  • Wei, Kuo-Chen Cheng (CoPI)
  • Yeh, Chih Kuang (CoPI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

The purpose of this three-year project intends to establish a molecular imaging-based translational platform to demonstrate the effectiveness and feasibility of brain drug delivery through tight junction with the technique of focused ultrasound induced blood-brain barrier (BBB) opening, which in on going developed from our group. In this three-year project, we aim to construct a universal platform which intends to provide novel treatment technology as well as therapeutic means to be translational and brings the opportunity to be of clinically impact. We (from the General project) will be used to support the focused ultrasound brain-drug delivery technology for the assessment of BBB-disruption and brain drug delivery by using small-animal brain-tumor model as our target. Other sub-projects will support to develop specific novel molecular imaging technology including the focused ultrasound induced BBB opening technology, , Quantitative molecular imaging technology as the second tool (Sub-project #1), High-frequency ultrasonic imaging and liposome based microbubbles as the third molecular imaging tools (Sub-project #2), and the Photoacoustic imaging technology as well as the nanorods as the 4th molecular imaging tools (Sub-projects #3). Technology needs to be established in this general application includes: (1) In order to achieve the goal of establishing a molecular imaging-based translational platform for focused ultrasound induced brain drug delivery, the following techniques from this application (General project) will be developed; (2) To establish a rat glioma multiform (GBM) brain tumor model; (3) To establish microarray and tissuomics assay rat GBM model for validation at molecular and cellular level; (4) To establish an integrated pre-clinical multi-modalities molecular imaging software for rat GBM to validate drug delivery system using focused ultrasound technique to open BBB opening in rat brain; (5) To establish a system approach informatics in rat GBM, before and after treatment using focused ultrasound to open the BBB and compare with the result of traditional treatment mode.

Project IDs

Project ID:PC9812-0317
External Project ID:NSC98-2218-E182-008
StatusFinished
Effective start/end date01/11/0931/10/10

Keywords

  • focused ultrasound
  • drug delivery
  • molecular images
  • microarray
  • tissuomics

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