Establish a Novel Screening System for Discovery of Anti-Aging Drugs: Screen Potential Herbal Medicines for Life Extension and Investigate Their Molecular Mechanisms

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

Aging, the accumulation of change in a creature over time, is a universal process for almost all multicellular organisms that coincides with increased morbidity and mortality. The ROC Minister of the Interior estimated that the percentage of people aged 65 years and older in Taiwan will increased from 10.7% in 2010 to 24.4% in 2030. The number of people suffering from aged-related diseases is anticipated to more than double over the next two decades. Interventions that can decelerate aging processes continue to raise interest among medical research. Besides, the molecular mechanisms underlying aging appear to be interconnected the same pathways with age-related diseases. Therefore, drugs and dietary regimens that can extend lifespan could potentially be used to treat age-related diseases. The budding yeast Saccharomyces cerevisiae has been used extensively to study the fundamental processes of aging and age-related study. In this project, we will first establish a novel screening system for discovery of drugs that can extend lifespan in yeast. Next, we will screen potential herbal medicines for life extension and investigate their molecular mechanisms in yeast, mammalian cells as well as in mouse models. Finally, we will identify the roles of these drugs in age-related disorder therapy (for example, type II diabetes). The main purpose of this project is the screening and identification of drugs that could achieve human healthy aging, where improved longevity is coupled to a corresponding healthspan extension.

Project IDs

Project ID:PC10507-0106
External Project ID:MOST105-2320-B182-001
StatusFinished
Effective start/end date01/08/1631/07/17

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