Establishment of a Neurotransmitter Detection Platform by Bioelectrochemical Analysis and Positron Emission Tomography (Pet)(Ii)

This two-year proposal is a continuous research work based on the approved MOST project (MOST 106-2221-E-182-021). With the help of positron emission tomography (PET), this study utilizes bioelectrochemical analysis as a key technology to establish a highly sensitive analysis platform for the investigation of neurotransmitters. Recent studies suggest that physical activity plays an important role to mediate neuroplasticity. The connection between neurotransmitters and learning capabilities as well as further exploration of exercise’s impact on neuroplasticity will be studied using an animal model to assess mental capabilities and aerobic training. The mechanism of this is an area worth exploring to gain more precise insight into the process of remodeling of the nervous system. Improving the detection of neurotransmitters is the first priority of this study to better understand their physiological function. To this end, the core aspect of this study will seek to improve both sensitivity and selectivity for electrochemical sensors through modifying the working electrode. We will investigate the sensitivity of different nanocomposites as materials to modify the electrode as the electrode materials play a crucial role in the efficacy of sensing platforms; furthermore, we will also refine the detection by utilizing a novel PET radiotracer targeting vesicular monoamine transporter type 2, with a high sensitivity for detecting dopaminergic integrity in vivo, to detect the dopamine levels in the brain and further characterize the concentration and distribution of neurotransmitters. This study aims to fabricate the highly sensitive electrochemical sensor with multidisciplinary analysis for application of clinical medicine to discuss the dynamic interaction between neurotransmitter regulation, changes in central nervous system imaging, and aerobic training with an overarching goal of unveiling the mysteries regarding the functionality of the brain and propose possible mechanisms for aerobic exercise as an intervention to stimulate neuroplasticity.

Project ID:PB10707-0621
External Project ID:MOST107-2221-E182-021