Establishment of Integrative Microprotein Analysis Platform for Eukaryotes

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

微小蛋白質是一個相對新穎的研究領域,目前僅有人類與少數模式物種有相關研究。本計畫以「建立真核模式生物微小蛋白質整合式分析平台」為目標,先以演化上較古老的單細胞原生動物為出發點,再擴展到所有真核生物。以生物資訊方法建立完整真核生物微小蛋白質序列資料庫,再導入最新的次世代RNA定序、核糖體圖譜定序與第三代RNA直接定序技術,同時配合質譜數據,以多體學實驗技術鑑定各物種共有或特有微小蛋白質的存在。若研究順利進行,研究成果除了能提供微小蛋白質系統性驗證分析平台外,將來更可延伸至致病原分子鑑定與藥物開發。其重要性不可言諭。

Project IDs

Project ID:PB11207-2760
External Project ID:NSTC111-2221-E182-052-MY3
StatusActive
Effective start/end date01/08/2331/07/24

Keywords

  • microprotein
  • sORFs
  • nanopore sequencing
  • NGS
  • Ribo-Seq
  • multi-Omics
  • eukaryotic
  • genome annotation
  • functional prediction
  • differentially expressed genes

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