Establishment of Intrahepatic Cholangiocarcinoma Mice Model to Explore Immune Microenvironment and Anti-Pd1 Treatment Biomarkers

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

建立的膽道癌小鼠模型適用於體內和體外實驗。原位肝臟接種生成腫瘤及自發性遠處轉移提供了完整的平台來評估原發部位和轉移部位免疫微環境的差異。此模型獨特地結合了原位移植和基因工程小鼠模型的優勢,提供了一個具有免疫健全且快速和可擴展數量的小鼠平台,用於探索預測免疫反應的生物標誌物和創新的免疫治療。

Project IDs

Project ID:PC11307-1468
External Project ID:NSTC113-2314-B182-028
StatusActive
Effective start/end date01/08/2431/07/25

Keywords

  • cholangiocarcinoma
  • in vivo model
  • immune microenvironment
  • immunotherapy

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