Evaluation of Fgf19 Role in Cholangiocarcinoma and Application the Newest Vitamin D Analog, Mart-11, to Treat Cholangiocarcinoma

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

尋找新的膽道癌治療標的及制劑是刻不容緩。FGF 19在乳癌,口腔癌,肝癌,肺癌中已被發現FGF 19過度表現和病人的預後成反比。我們初步的實驗結果發現FGF 19 knockdown 或 overepxression會減少或增加 膽道癌細胞的生長及轉移,另外我們已證實1α25(OH)2D3 及它的類似物MART-10可以有效的在細胞及動物實驗中抑制膽道癌細胞生長,並已發表論文。在這個計畫中,我們將研究FGF 19在膽道癌的詳細角色及調控機轉。另外我們會使用最新的1α25(OH)2D3類似物,MART-11,來治療膽道癌,我們這個研究有機會對膽道癌提供更多的治療方向及藥物,改善膽道癌病人的預後。

Project IDs

Project ID:PC11008-0313
External Project ID:MOST108-2314-B182-067-MY3
StatusFinished
Effective start/end date01/08/2131/07/22

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