Project Details
Abstract
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, and the
major cause to induce the clinical symptoms of PD is its huge loss of dopamine neuron in
the substantial nigra and the profound loss of dopamine in the dopaminergic neuron terminal.
So far, the pathogenesis factor of PD is still unclear, as such, there are many PD animal
models have been proposed to study the PD progression. Furthermore, the 6-OHDA-induced
PD animal model has been used as a solid platform to screen many newly synthesized drugs
which were aimed for PD treatment. Magnolol and honokiol have been proved their
treatment efficacy on 6-OHDA PD animal model. This project tempts to evaluate the
restorative effect with a synthetic honokiol derivative MH101 on 6-OHDA-induced
neurotoxicity in a hemiparkinsonism mouse model using in vivo [18F]FP-(+)-DTBZ PET
and [123I]FP-CIT SPECT imaging.
Project IDs
Project ID:PC10302-0015
External Project ID:MOST103-2623-E182-001-NU
External Project ID:MOST103-2623-E182-001-NU
Status | Finished |
---|---|
Effective start/end date | 01/01/14 → 31/12/14 |
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