Evaluation of Restorative Effect of a Honokiol Derivative on Neurotoxicity in 6-Hydroxydopamine-Induced Parkinsonism Animal Model Using [18F]FP-(+)-DTBZ PET and [123I]FP-CIT SPECT

  • Wey, Shiaw-Pyng (PI)
  • Chan, Ming Huan (CoPI)
  • Hsiao, Ing-Tsung (CoPI)
  • Lin, Kun-Ju (CoPI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, and the major cause to induce the clinical symptoms of PD is its huge loss of dopamine neuron in the substantial nigra and the profound loss of dopamine in the dopaminergic neuron terminal. So far, the pathogenesis factor of PD is still unclear, as such, there are many PD animal models have been proposed to study the PD progression. Furthermore, the 6-OHDA-induced PD animal model has been used as a solid platform to screen many newly synthesized drugs which were aimed for PD treatment. Magnolol and honokiol have been proved their treatment efficacy on 6-OHDA PD animal model. This project tempts to evaluate the restorative effect with a synthetic honokiol derivative MH101 on 6-OHDA-induced neurotoxicity in a hemiparkinsonism mouse model using in vivo [18F]FP-(+)-DTBZ PET and [123I]FP-CIT SPECT imaging.

Project IDs

Project ID:PC10302-0015
External Project ID:MOST103-2623-E182-001-NU
StatusFinished
Effective start/end date01/01/1431/12/14

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