Evaluation of Treatment Response of Chemotherapy in Rat Brain Tumor Using Mri

Glioblastomas are the most common subtype of rapidly growing primary brain tumors, which are characterized by remarkable proliferative vascular components and are often necrotic and invasive. We propose a prospective study of multiparametric MR imaging using the following techniques in a single protocol for an comprehensive investigation of tumor progression in response to chemotherapy. A cultured C6 glioma cells in rat model will be used for the evaluation of treatment response after chemotherapy. Multiparametric MRI will include diffusion MRI (including diffusion tensor and kurtosis), dynamic contrast imaging (DCE) and blood oxygen dependence (BOLD) techniques for investigation the relationships among tumor cellularity, angiogenesis and hypoxia. The treatment response of chemotherapy will be assessed using the derived multifunctional parameters, which will be compared with the histology. A voxel-wise based approach, functional parametric map, will be established to evaluate the early response in predicting the later outcomes, which include survival rate and tumor growth rates as revealed by conventional anatomical images.

Project ID:PC10108-0904
External Project ID:NSC101-2314-B182-066