Fabrication and Characterization of Bioactive Coatings in Aqueous Solution (2)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

The success rate of tissue reconstitution depends on the internal structure of cell-containing scaffolds that can provide sufficient space for cell growth and provides suitable mechanical strength to support tissue regenerations during cells growth. However, the interaction strength between cells and scaffold depends on surface physical and chemical properties such as topography, polarity, wettability and zeta potential. Most synthetic biomaterials only meet mechanical requirement and absents of biological recognition sites. Meanwhile, the intrinsic hydrophobic property and the lack of function groups for bioconjugation of synthetic polymers limit its performance when used as tissue engineering scaffolds. Numerous of modification are developed in order to improve their hydrophilic properties and to achieve a friendly interface for living cells. However, only few of these can be transferred between substrate materials and even less will result in complex geometries. The present proposal describes a simple, water-based surface modification method that has the ability to alter any substrate materials. The spontaneous polymerization of aminomalonitrile (AMN) can be induced by neutralizing the commercially available salt in simple aqueous solutions. The modified process is a green process because no any organic solvents, initiators and catalysts would be used. We will fabricate a composite bone regeneration scaffold that composed with nano-ceramic-particles containing antibacterial drug which are embedded in nanofibers to demonstrate the efficiency of proposal process. In the proposal we would like to investigate the antibacterial drug performance of AMN-based coated three-dimensional scaffolds, with and without other co-monomers, and evaluate of AMN-based coating surfaces on mesenchymal stem cellular response.

Project IDs

Project ID:PB10707-0076
External Project ID:MOST107-2221-E182-020
StatusFinished
Effective start/end date01/08/1831/07/19

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