Fabrication and Characterization of Bioactive Coatings in Aqueous Solution

Interfacial interaction is the first contact between a medical device and a biological system. Scientists agree that the success of biomedical devices depends on their surface proper-ties. Well-designed surface physical and chemical properties, such as the texture, net charge, and hydrophilicity, can enhance cell attachment to the surface or antifouling. Today there is worldwide agreement that the success of the majority of biomedical devices, ranging from implantable medical devices to cell culture tools and diagnostic devices, depends on their surface properties. A broad range of surface modification methods have been developed to modify the surface of biomedical devices. However, only few of these can be transferred between substrate materials and even less will result in complex geometries. Meanwhile, water-based polymeric coating methods would be ideally used in biomedical devices. The present proposal describes a simple, water-based surface modification method that has the ability to alter any substrate materials. The spontaneous polymerization of aminomalonitrile (AMN) can be induced by neutralizing the commercially available salt in simple aqueous solutions. The modified process is a green process because no any organic solvents, initiators and catalysts would be used. We will fabricate a composite bone regeneration scaffold that composed with nano-ceramic-particles containing antibacterial drug which are embedded in nanofibers to demonstrate the efficiency of proposal process. In the proposal we would like to investigate physico-chemical properties of AMN-based coatings, with and without other co-monomers, and evaluate of AMN-based coating surfaces on cellular response.

Project ID:PB10607-1396
External Project ID:MOST106-2221-E182-020