Feasibility Assessment of Polygenic Risk Score-Stratified Screening in Hepatocellular Carcinoma

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

肝癌為台灣癌症死因第二位,多數肝癌患者為中年男性且為家庭主要經濟支柱,一旦患病對社會將造成重要負擔。透過篩檢以提早發現肝癌可有效改善肝癌患者存活率。現今台灣肝癌篩檢是以病毒性肝炎及肝硬化患者為主,然而近年來台灣病毒性肝炎防治成效卓著,加以生活習慣改變,使其他病因導致之肝癌比例在未來可能會逐漸上升。若能利用最新的疾病遺傳研究成果協助疾病篩查,則有機會找到傳統方式忽略之潛在患者。因此本計畫所提出的篩查策略是先將人群依肝癌遺傳風險進行分層,再依風險高低修正該人群最適之篩查策略,最後輔以成本效益評估以確認新策略之可行性。若能因此提高肝癌篩檢成效,早期發現肝癌,將可對社會及經濟提供相當大的助益。

Project IDs

Project ID:PC11207-1492
External Project ID:NSTC112-2314-B182-044
StatusFinished
Effective start/end date01/08/2331/07/24

Keywords

  • hepatocellular carcinoma
  • polygenetic risk score
  • cost-effective analysis
  • HCC screening

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