Functional Exploration of the Osmoreceptor Tmem63b in Adhd-Like Phenotype and Drug Addiction

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

1. RNA 編輯在功能角色上仍懸而未解,特別是編碼區域的RNA 編輯物目標。本研究將深入探討一新穎之穿膜蛋白Tmem63B在細胞與個體中所扮演的角色,以及再編碼變異體對其功能之影響,將能更加瞭解RNA 編輯對神經系統及生物體發育上的意義。2. 利用CRISPR技術建立Tmem63b基因剃除鼠和其全編輯位點基因植入鼠,發現Tmem63b的異常會導致實驗鼠有過動和學習困難等病徵。此模式鼠將幫助進一步了解孩童過動之原因,也將探討臨床上使用類安非他命治療過動症和易於成癮之調控機制。

Project IDs

Project ID:PC11107-5358
External Project ID:MOST110-2326-B182-001-MY3
StatusFinished
Effective start/end date01/08/2231/07/23

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